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Clinical Studies for People Either With or Without Diabetes

SUGAR MGH Study: Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans

Description: The SUGAR MGH Research Study will evaluate whether the different genes people inherit change the response to medications that are commonly used to treat type 2 diabetes, metformin and glipizide.  As part of the study participants will be asked to take these medications and will also be given a sugar drink. 

The study involves two visits to the Joslin Diabetes Clinic one week apart, the first visit takes about 5 hours and the second about 3 hours.  Blood will be drawn at both visits.  Participants will receive monetary compensation, a parking voucher and a free meal for each completed visit. 

Recruiting: We are seeking research volunteers over the age of 18 years who have diabetes but are not currently on diabetes medication, and/or who may be at risk for diabetes (for example, risk factors include high or “borderline-high” blood sugars, being overweight, having a history of gestational diabetes (diabetes during pregnancy), being an ethnic minority, or having a first degree relative with type 2 diabetes). 

Contact: If you are interested in learning more about the study, please feel free to contact Corinne Barbato at 617-309-4478 or email at

(CHS #2007-000193)