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Studies for People Without Diabetes

CIRT: Cardiovascular Inflammation Reduction Trial

Description: We are seeking study volunteers who have had a heart attack or been diagnosed with coronary heart disease in the last 5 years to join a research study at the Joslin Diabetes Center to study if reducing inflammation with low-dose methotrexate, a very common anti-inflammatory drug, can lower the risk of having future heart attacks, strokes, or dying from heart disease. This study will include taking methotrexate or placebo for around 3 years, and bimonthly visits with blood draws. Compensation for time and parking is provided.

Recruitment: You may be eligible to participate in CIRT if you have had a heart attack or been diagnosed with coronary heart disease in the past 5 years, and you have either diabetes or a condition called “metabolic syndrome”.

Contact: If you are interested in participating, contact the Study Coordinator, Jackie Piper at: (617)-309-4725 or CIRT@joslin.harvard.edu

(CHS #2013-06)

TrialNet Natural History Study for the Prevention of Type 1 Diabetes

Description: The study aims to identify youth and adults at risk for type 1 diabetes by testing for diabetes-related antibodies in relatives of people with type 1 diabetes.  It involves a single blood test.  People who test positive will be eligible for further testing and may be eligible to participate in prevention  trials.

Recruitment: Parents, children, & siblings, ages 1-45, and cousins, grandchildren, nieces, & nephews, ages 1-20, of people with type 1 diabetes.

Contact: If you are interested in learning more about the study, please contact Sarah Szubowicz at (617) 309-4493 or sarah.szubowicz@joslin.harvard.edu

(CHS #03-33)

Does a nutrient found in beets reduce diabetes risk?

Description: In this clinical research study we are evaluating whether supplementation of a naturally occuring component found in beets and other vegetables and grains reduces diabetes risk. The product we are studying is a modified amino acid that is important in several metabolic pathways and lower in patients with diabetes and cardiovascular risk factors.  Participants will have a glucose tolerance test, commonly used to diagnose type 2 diabetes and if prediabetic will be randomized (like the flip of a coin) to receive the supplement or a placebo. Measurements of insulin sensitivity, liver fat, and blood vessel function will occur before and after 3 months of supplementation, requiring two days and the overnight stay at the beginning and again at the end of the study with two additional morning visits during the study.

Recruiting: We are seeking clinical Research Volunteers with risk factors for type 2 diabetes or prediabetes who are overwheight, between 21-65 years of age, who are willing to help us learn about the effects of naturally occurring food substances on cardimetabolic health.

Contact: If you are interested in learning more about the study, please contact Ana Maria Grizales, MD at 617-309-4736 or email Ana.Grizales@joslin.harvard.edu

(CHS #2013-103)

 

 

 

Page last updated: July 30, 2016