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Research volunteer opportunities - type 2

SLIMM T2D Study: Surgery of Lifestyle with Intensive Medical Management in the treatment of Type 2 Diabetes

Description: We are comparing whether bariatric surgery (weight loss surgery) or a diabetes and intensive medical and weight management program is more effective for the treatment of type 2 diabetes in patients who are modestly overweight.

Participants will be randomized (like the flip of a coin) to surgical or non-surgical treatment.

Participants randomized to surgery will have their surgery performed at the Brigham and Women's Hospital, Boston.  Follow up visits for surgical groups can vary based on the type of surgery performed.

Those participants randomized to the Intensive Medical Management program will have several visits at the Joslin Diabetes Center, Boston which include the following:  Weekly evening meetings over 13 weeks for group education and support led by a physician, diabetes nurse educator, nutritionist, exercise physiologist and behavior counselor

Monthly follow up visits after 13 weeks. Both surgical and non-surgical groups are followed over three years.

Recruiting: We are seeking clinical Research Volunteers with type 2 diabetes and excess weight, between 21-65 years of age, who are willing to have bariatric (weight loss) surgery or participate in an intensive medical (non-surgical) diabetes and weight management program.

Contact: If you are interested in learning more about the study, please contact Kerri Clancy at 617-525-7388 or email

(CHS #2010-18)

Do you have Type 2 diabetes and take insulin?

Description:  We are conducting a research study involving people with type 2 diabetes and adjusting insulin and other medications to reduce after-mean blood sugar spikes.  

Recruiting: You may be eligible to participate if you are a type 2 diabetes patient between the ages of 45-75 years old , take insulin, and your last A1c was about 7.5 -8.5%. You must also have any of the following: 1) high blood pressure, 2)high cholesterol, 3)tobacco use and 4)a Body Mass Index (BMI) of 25-40.

Eligible participants who take part in the study will receive monetary compensation, parking validation for study visits, and all study-related diabetes medications during study period.

Contact: For more information or to find out if you are eligible, contact Stephanie Edwards at 617-309-1996 or email

(CHS # 2012-05)


Volunteers needed in diabetes study

Description: Do you want to contribute to cutting edge research in diabetes? The Joslin Diabetes Center in Boston is conducting a new research study to investigate Induced Pluripotent cells (iPS) in diabetes. Induced pluripotent cells (iPS) are cells that can be grown forever in a laboratory and can become other types of cells. These cells may someday help us to predict who is at risk of developing diabetes, which may lead to a better understanding of the disease process or possible new therapies . 

Recruiting: If you are between 18-70 years of age with or without diabetes you may be eligible to participate in the study. Participants will come to the Joslin Diabetes Center in Boston 1-2 times, complete a health history and have a brief physical exam, give a sample of blood, urine and a skin biopsy, have cells grown in a laboratory from their skin sample indefinitely for future use.Parking will be covered, although there is no other compensation for participating in this study.

Exclusions include: history of bleeding disorders, and history of irregular heart rhythms.

Contact: For more information about this study, please call Julia Ramus at 617-309-4322, or email

(CHS # 08-22)

The SIMPLE Study: Simplified Insulin Management protocol using Lantus in Elderly

Description: The SIMPLE study is looking to understand if simplifying diabetes treatment regimen, by decreasing the number of insulin injections, can decrease the episodes of low blood glucose in patients with type 2 diabetes.  The study involves 6 visits over an 8-month period, though not all need to be completed at Joslin.  Many of the visits can be completed on the same days as regular clinic appointments, but some visits will occur between appointments.

During the study all insulin will be provided to you at no cost and monetary compensationis available for each visit.

Recruiting: Patients over 70 with type 2 diabetes who are on two or more injections of insulin a day.

Contact:  If you are interested in learning more about the study, please contact Christine Slyne at 617-309-4683 or


The Brain and Nutrition Study

Description: The Brain and Nutrition Study is studying how people with type 2 diabetes think and decide about food and activity.  If successful, this study may lead to innovations for understanding how patients learn about diabetes.

The study has 2 visits.  Visits include surveys, A1c, CGM placement, a diabetes game, a drawing activity, a short walking exercise and a brain MRI scan.

Recruitment: You may be eligible if you are a Joslin patient with type 2 diabetes between 35 and 60 years old and on diabetes medication.

Proficiency in English is required.  Monetary compensation for study visits and three hours of parking for each study visit are provided.

Contact: If you are interested in learning more about the study, please call Dana Bruck-Segal at 617-309-3449 or email at or call Jessica Blais at 617-309-2403 or email at


The Effects of Type 2 Diabetes on Brain Function Study

Description: In this study, we are looking at whether people with Type 2 diabetes show early signs of changes in their thinking processes.We are looking for people both with and without type 2 diabetes so we can compare their thinking processes.  The study involves 2 visits, one 2-4 hour visit to the Joslin Diabetes Center and one 1 hour visit to Beth Israel Medical Center in Boston.  Study procedures involve thinking tests, completing questionnaires, blood tests and a MRI Scan to examine performance on thinking tests.People without a prior diagnosis of diabetes will also be given a sugary drink at their visit to see how their body processes sugar.

Recruiting: Seeking participants between the ages of 45-65 with a diagnosis of Type 2 Diabetes who are not on metformin, or TZD's (pioglitazone, rosiglitazone).  We are also seeking participants between the ages of 45-65 who have not been diagnosed with Diabetes.

Moderate proficiency in English is Required.   Monetary compensation is available and the study will validate parking on days of study visits.

Contact: If you are interested in learning more about this study, please call Thomas Marder at 617-309-4326 or email


Are you having gastric bypass surgery? Do you have type 2 diabetes?

We are looking for clinical research volunteers who are going to have a gastric bypass surgery for weight loss at Brigham and Women’s Hospital and who have type 2 diabetes. We are conducting a study on how gastric bypass weight loss surgery helps to improve blood sugars in those with type 2 diabetes.

The study involves 3 visits before your surgery, and 2 visits afterwards. The first visit will be at either Brigham and Women’s Hospital or Joslin Diabetes Center, and all the visits after that will be at Joslin Diabetes Center. During these visits we will study how your body responds to sugar and the hormone insulin.

We are looking for people 21 to 60 years of age. You will be compensated for your time. Please contact us if you would be willing to participate in this important research study.

For more information, contact Jennifer Panosian at 617-264-2731 or email


Sleep effectiveness and glucose and insulin homeostasis

Description:The Beth Israel Deaconess Medical Center is conducting a research study to see how sleep quality impacts blood sugar control and the body’s handling of energy. We will test whether a commonly prescribed sleep medication called Eszopiclone (Lunesta) might improve blood sugar control by improving quality of sleep. It is a 10 day / 10 night study with all testing in your home environment. We will obtain information about your blood sugar levels and sleep at your baseline and during the time you take the study medication.

Recruiting:Type 2 diabetics and people with pre-diabetes, ages 18-64 years old, who keep a regular sleep schedule, do not take medications for sleep or stimulants, do not have sleep apnea, and are free of tobacco or illegal substances. Pregnant or lactating woman may not participate as there may be hormonal effects on the study findings.

Prediabetes means that you are at risk for developing diabetes based on specific criteria (such as having an elevated blood sugar level or an abnormal response to a sugary drink-glucose tolerance test performed by your doctor). People with relatives with diabetes might also have increased diabetes risk.

Contact:For additional information about this study, please contact Chris Wood at

(CHS #2012-P-000187)