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Pathophysiology of Diabetes

Activity Description

CME Release Date: 1/11/2011
CME Expiration Date: 1/112012

This Internet enduring material activity was developed from a presentation made at the live symposium titled Joslin Diabetes Forum 2010: Advancing the Impact of Care that took place on September 11, 2010, in Baltimore, MD.

This activity is supported through educational grants provided by Amylin Pharmaceuticals, Inc., and Lilly USA LLC, Daiichi Sankyo, Inc., Genentech, and sanofi-aventis U.S.

Statement of Need

Clinical management of diabetes is no longer just about glucose control; the current approach requires that clinicians address a complex array of cardiometabolic risk factors including hypertension, dyslipidemia, and weight management in addition to diabetes, all of which require both nonpharmacologic and pharmacologic interventions. To reduce morbidity, mortality, and the personal burden of diabetes among their patients, primary care clinicians face the challenge of designing, initiating, and advancing complex physiologic-based treatment plans. This workshop will strengthen your diabetes knowledge and management skills, including how to understand and integrate the implications of recent research developments into clinical practice. You will also learn how the development of efficient office-based systems can facilitate early identification and intervention for your high-risk patients, leading to improved patient outcomes.

Topics

  1. Defining Diabetes and Insulin Resistance
  2. The Insulin-Resistant State
  3. Beta-Cell Dysfunction
  4. Diagnosis, Classification, and Impact of Type 2 Diabetes
  5. Glucagon in Type 2 Diabetes
  6. Incretins and Glucose Homeostasis
  7. Type 2 Diabetes and Obesity
  8. Fat Cells and Atherosclerosis
  9. Inflammation: The Connection among Cardiovascular Disease Risk Factors

Target Audience

This certified CME Internet enduring material activity has been developed for primary care providers and both clinical and office staff who treat patients with diabetes. There is no fee to participate in this activity.

Learning Objectives

Participants will be provided with clinically relevant, evidence-based information.
Upon completion of this activity, participants should be able to:

  • Describe the pathophysiologic abnormalities of diabetes, including insulin deficiency, insulin resistance, and alpha cell/glucagon abnormalities
  • Discuss the diagnostic criteria for diabetes
  • Explain the actions of the incretins in glucose homeostasis
  • Describe the links between type 2 diabetes and fat, inflammation, and atherosclerosis

Faculty and Disclosures

Kirit Tolia, MD, FACE
Clinical Associate Professor of Medicine
Wayne State University
Detroit, MI
Chief of Endocrinology and Joslin Diabetes Center Affiliate at Providence Hospital
Southfield, MI

Disclosure: Dr. Kirit Tolia is on the speakers bureau for Amylin Pharmaceuticals, Inc., AstraZeneca Pharmaceuticals LP, Bristol-Myers Squibb Company, GlaxoSmithKline, Merck & Co., Inc., Pfizer Inc, and Daiichi Sankyo, Inc., and is on the speakers bureau and receives grant/research support from Eli Lilly and Company and Novo Nordisk Inc.

Planning Committee:

Richard S. Beaser, MD*
Associate Clinical Professor of Medicine
Harvard Medical School
Medical Executive Director
Professional Education
Joslin Diabetes Center
Boston, MA

Disclosure: Dr. Richard S. Beaser is a consultant for CeQur Ltd.

Julie A. Brown*
Director
Professional Education
Joslin Diabetes Center
Boston, MA

Disclosure: Julie A. Brown has no relevant financial relationships.

Karen J. Kuc*
Assistant Director, Grants and Projects
Professional Education
Joslin Diabetes Center
Boston, MA

Disclosure: Karen J. Kuc has no relevant financial relationships.

James E. Neighbours, MEd*
Associate Director, Education Design
Professional Education
Joslin Diabetes Center
Boston, MA

Disclosure: James E. Neighbours has no relevant financial relationships.

Eyiuche Okeke, MD
Instructor in Medicine
Harvard Medical School
Outcomes Investigator
Department of Professional Education
Staff Endocrinologist
Joslin Diabetes Center
Boston, MA

Disclosure: Dr. Euyiche Okeke has no relevant financial relationships.

Kenneth J. Snow, MD, MBA*
Assistant Professor of Clinical Medicine
Harvard Medical School
Senior Physician, Adult Diabetes Section
Joslin Diabetes Center
Boston, MA

Disclosure: Dr. Kenneth J. Snow has no relevant financial relationships.

*Also on the CME Advisory Committee


CME Advisory Committee

Enrique Caballero, MD
Director, Medical Affairs
Professional Education
Director, Latino Diabetes Initiative
Joslin Diabetes Center
Boston, MA

Disclosure: Dr. Enrique Caballero is a consultant and on the speakers bureau and scientific advisory board for Amylin Pharmaceuticals, Inc., AstraZeneca Pharmaceuticals LP, Bristol-Myers Squibb Company, Daiichi Sankyo, Inc., and Eli Lilly and Company.

Jerry Cavallerano, OD, PhD
Optometrist
Beetham Eye Institute
Joslin Diabetes Center
Boston, MA

Disclosure: Dr. Jerry Cavallerano has no relevant financial relationships.

A. Patrick Egan, MD
Family Practice
Internal Medicine Specialist
Dorchester House Multi-Service Center
Boston, MA

Disclosure: Dr. A. Patrick Egan has no relevant financial relationships.

Ann E. Goebel-Fabbri, PhD
Instructor in Psychiatry
Harvard Medical School
Psychologist
Behavioral and Mental Health Unit
Joslin Diabetes Center
Boston, MA

Disclosure: Anne E. Goebel-Fabbri has no relevant financial relationships.

Osama Hamdy, MD, PhD, FACE
Assistant Professor of Medicine
Harvard Medical School
Medical Director, Obesity Clinical Program
Joslin Diabetes Center
Boston, MA

Disclosure: Dr. Osama Hamdy is on the speakers bureau for Amylin Pharmaceuticals, Inc., Bristol-Myers Squibb Company, Merck & Co., Inc., Novo Nordisk Inc., and Takeda Pharmaceuticals North America, Inc.

Jonathan Scoble
Grants Manager
Professional Education
Joslin Diabetes Center
Boston, MA

Disclosure: Jonathan Scoble has no relevant financial relationships.

Robert C. Stanton, MD
Associate Professor of Medicine
Harvard Medical School
Chief of Nephrology
Joslin Diabetes Center
Boston, MA

Disclosure: Dr. Robert C. Stanton has no relevant financial relationships.

Howard A. Wolpert, MD
Assistant Professor of Medicine
Harvard Medical School
Director, Insulin Pump Program
Senior Physician
Joslin Diabetes Center
Boston, MA

Disclosure: Dr. Howard A. Wolpert is a consultant for Abbott Diabetes Care; Becton, Dickinson and Company; Insulet Corporation; and Novo Nordisk, Inc.

Accreditation and Designation of Credit

Joslin Diabetes Center, Boston, is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Joslin Diabetes Center designates this educational activity for a maximum of 0.75 AMA PRA Category 1 Credits.TM Physicians should only claim credit commensurate with the extent of their participation in the activity.

This CME activity was planned and produced in accordance with ACCME Essentials.

Participants not eligible for continuing medical education credit will receive a certificate of participation.

Computer Requirements

To participate in this activity, your computer will need the following hardware and software:

Credit Instructions

  1. Read the learning objectives, accreditation information, and faculty disclosures at the beginning of the activity.
  2. Read the text and view the slides.
  3. Complete the posttest and evaluation.
  4. Physicians who receive a grade of 70% or better on the posttest and who complete the evaluation will receive immediate CME credit.
  5. All other participants who receive a grade of 70% or better on the posttest and who complete the evaluation will receive a certificate of participation.

Questions About This Activity

For questions regarding the content of this activity, contact the accredited provider for this CME activity: cme@joslin.harvard.edu

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Page last updated: April 24, 2014