For Scientists Research Information Alumni Connection

Publications

 

2012

Liew, C.W., Boucher, J., Cheong, J.K., Vernochet, C., Mallol, C., Townsend, K., Langin, D., Kawamori. D,, Hu. J, Tseng, Y-H, Hellerstein, M.K., Farmer, S.R., Goodyear, L., Doria, A., Bluher, M., Hsu, SI-H, Kulkarni, R.N.*. Ablation of TRIP-Br2, a novel regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat Medicine (in press)

Teo, A.K., Kulkarni, R.N. (2012)Setting sail for glucose homeostasis with the AKAP150-PP2B-anchor. EMBO J. 2012 Oct 17;31(20):3956-7. http://www.ncbi.nlm.nih.gov/pubmed/22983555

Negahdar, M., Aukrust, I., Johansson, B.B., Molnes, J., Molven, A., Matschinsky, F.M., Sovik, O., Kulkarni, R.N., Flatmark, T., Njolstad, P.R., and Bjokhaug, L. (2012) GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation. Biochimica et Biophysica Acta. Nov;1822(11):1705-15. http://www.ncbi.nlm.nih.gov/pubmed/22820548

Welters, H., El Ouaamari, A., Kawamori, D., Meyer, J., Hu, J., Smith, D., and Kulkarni, R. N. (2012). Rosiglitazone promotes PPARgamma dependent and independent alterations in gene expression in mouse islets. Endocrinology. Oct;153(10):4593-9. http://www.ncbi.nlm.nih.gov/pubmed/22807489

Kulkarni, RN. Identifying biomarkers of subclinical diabetes. (2012) Diabetes Aug 61(8):1925-6 http://www.ncbi.nlm.nih.gov/pubmed/22826312  

Kulkarni, R.N., Bernal-Mizrachi E., Garcia-Ocana A., Stewart AF. (2012) Human beta cell proliferation and intracellular signaling: driving in the dark without a roadmap. Diabetes. Sep;61(9):2205-13. http://www.ncbi.nlm.nih.gov/pubmed/22751699

Goldfine A.B., Kulkarni, R.N. (2012) Insulin modulation of beta cell function: a translational journey from the bench to the bedside. Diabetes Obesity Metab. 2012 Oct;14 Suppl 3:152-60.  http://www.ncbi.nlm.nih.gov/pubmed/22928576

Morioka T., Dishinger J.F., Reid K.R., Liew C.W., Zhang T., Inaba M., Kennedy R.T., Kulkarni R.N. (2012). Enhanced GLP-1- and Sulfonylurea-Induced Insulin Secretion in Islets Lacking Leptin Signaling. Mol Endocrinol. Jun;26(6):967-76 http://www.ncbi.nlm.nih.gov/pubmed/22474124

Kim W., Lao Q., Shin Y-K., Carlson O.D., Lee E.K., Gorospe M., Kulkarni R.N., Egan J.M. (2012). Cannabinoids induce pancreatic beta-cell death by directly inhibiting insulin receptor activation. Science Signaling. Mar 20;5(216):ra23 http://www.ncbi.nlm.nih.gov/pubmed/22434934

Kebede M., Ferdaoussi M., Mancini A., Alquier T., Kulkarni R.N., Walker M.D., Poitout V. (2012). Glucose activates GPR40 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1. Proc Natl Acad Sci. Feb 14;109(7):2376-81. http://www.ncbi.nlm.nih.gov/pubmed/22308370

Lee E.K., Kim W., Tominaga K., Martindale J.L., Yang X., Subaran S.S., Carlson O.D., Kulkarni R.N., Akamatsu W., Okano H., Egan J.M., Gorospe M. (2012). RNA-binding protein HuD controls insulin translation. Molecular Cell. Mar 30;45(6):826-35. http://www.ncbi.nlm.nih.gov/pubmed/22387028

Halperin, F., Lopez, X., Manning, R., Kahn, C.R., Kulkarni, R.N., Goldfine, A.B. (2012). Insulin augmentation of glucose stimulated insulin secretion is impaired in insulin resistant humans. Diabetes. Feb;61(2):301-9. http://www.ncbi.nlm.nih.gov/pubmed/22275085

Galkina E, Butcher M, Keller SR, Goff M, Bruce A, Pei H, Sarembock IJ, Sanders JM, Nagelin MH, Srinivasan S, Kulkarni RN, Hedrick CC, Lattanzio FA, Dobrian AD, Nadler JL, Ley K. (2012) Accelerated atherosclerosis in Apoe-/- mice heterozygous for the insulin receptor and the insulin receptor substrate-1. Arteriosclerosis, Thrombosis and Vascular Biology. Feb;32(2):247-56. Epub 2011 Dec 22. http://www.ncbi.nlm.nih.gov/pubmed/22199371

 

2011

Folli F, Okada T., Perego, C., Gunton, J., Liew, C.W., Akiyama M, D' Amico A, La Rosa S, Placidi C, Lupi R, Marchetti P, Sesti G, Hellerstein M, Perego L, Kulkarni RN. (2011) Altered insulin receptor signalling and b-cell cycle dynamics in type 2 diabetes mellitus. PLoS One. 6(11):e28050 http://www.ncbi.nlm.nih.gov/pubmed/22140505

Rowland, K.J., Trivedi, S., Lee, D., Wan, K., Kulkarni, R.N.,Holzenberger, M., Brubaker, P.L. (2011) Loss of Glucagon-Like Peptide-2 induced Proliferation following Intestinal Epithelial Insulin-Like Growth Factor-1 Receptor Deletion. Gastroenterology,141(6):2166-2175 http://www.ncbi.nlm.nih.gov/pubmed/21925122

Lopez, X., Cypress, A., Manning, R., O'Shea, S., Kulkarni, R.N., Goldfine, A.B. (2011) Exogenous insulin enhances glucose-stimulated insulin secretion in healthy humans independent of changes in free fatty acids.  J Clin Endocrinol Metab. Dec;96(12):3811-21.  http://www.ncbi.nlm.nih.gov/pubmed/21956413

Dirice E, Kulkarni RN. Pathways regulating b-cell regeneration in type 1, type 2 and gestational diabetes. In Kulkarni R.N., ed. Islet Growth Factors. Landes Bioscience, pp 1-22, 2011. http://www.landesbioscience.com/curie/chapter/4652/

Morioka T, Kulkarni RN. Pancreatic islet b-cell failure in obesity. Chapter 11; In Metabolic basis of obesity, ed. Ahima R. Springer Science (in press), 2011.

Spiegel, A., Carter-Su C., Taylor, S.I., Kulkarni, R.,N. Mechanism of action of hormones that act at the cell surface. In Melmed S, Polonsky KS, Larsen PR, Kronenberg HM. Williams Textbook of Endocrinology. 12th edition. Saunders, 2011

Reiner, T., Thurber, G., Gaglia, J., Vinegoni, C., Liew, C.W., Upadhyay, R., Kohler, R.H., Li, L., Kulkarni, R.N., Benoist, C., Mathis, D., Weissleder, R. (2011) Accurate measurement of pancreatic islet {beta}-cell mass using a second-generation fluorescent exendin-4 analog. Proc Natl Acad Sci 108(31):12815-20 http://www.ncbi.nlm.nih.gov/pubmed/21768367

Lin,W., Cao, J., Liu, J., Beshiri, M, Fujiwara, Y., Francis, J.M., Cherniack, A., Geisen, C., Blair, L.P., Zou, M., Shen, X., Kawamori, D., Liu, Z., Grisanzio, C., Watanabe, H., Minamishima, Y., Zhang, Q., Kulkarni, R.N., Signoretti, S., Rodig, S.J., Bronson, R.T., Orkin, S.H., Tuck, D.P., Benevolenskaya, E., Meyerson, M., Kaelin, W.G., Yan, Q. (2011) Loss of the RBP2 histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc Natl Acad Sci 108(33):13379-86. http://www.ncbi.nlm.nih.gov/pubmed/21788502

Kawamori, D., Akiyama, M., Hu, J., Hambro, B., Kulkarni, R.N. (2011) Growth factor signaling in the regulation of a-cell fate. Diabetes Obes Metab 13, Suppl 1:21-30 http://www.ncbi.nlm.nih.gov/pubmed/21824253

Zhou, J.Y., Dann, G.P., Liew, C.W., Smith, R.D., Kulkarni, R.N., Qian, W.J. (2011) Unraveling Pancreatic Islet Biology by Quantitative Proteomics. Expert Reviews of Proteomics 8(4):495-504 http://www.ncbi.nlm.nih.gov/pubmed/21819304

Kawamori, D., Kulkarni, R.,N. Molecular mechanism for the intra-islet regulation of glucagon secretion. "Hypoglycemia / Book 2" 2011 InTech (ISBN 979-953-307-245-5)

Kim, W., Doyle, M. E., Liu, Z., Lao, Q., Shin, Y-K., Carlson, O. D., Kim, H-S., Thomas, S., Napora, J. K., Lee, E. K., Moaddel, R., Wang, Y., Maudsley, S., Martin, B., Kulkarni, R. N., and Egan, J. M. (2011) Cannabinoids inhibit insulin receptor signaling in pancreatic beta cells. Diabetes 60(4):1198-209 http://www.ncbi.nlm.nih.gov/pubmed/21346174

Hinault, C., Kawamori, D., Liew, C. W., Maier B., Hu, J., Keller, S. R., Mirmira, R. G., Scrable, H. and Kulkarni, R. N. (2011) Delta 40 isoform of p53 controls b-cell proliferation and glucose homeostasis in mice. Diabetes 60(4):1210-22 http://www.ncbi.nlm.nih.gov/pubmed/21357466                                 

 

2010

Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, Yoshida M, Kakei M, Kitamura T, Luo J, Kulkarni RN, Kahn CR, Kasai H, Cantley LC, Kadowaki T. (2010) Class IA phosphatidylinositol 3-kinase in pancreatic beta-cells controls insulin secretion by multiple mechanisms. Cell Metab. 12(6):619-32. http://www.ncbi.nlm.nih.gov/pubmed/21109194

Kulkarni R. N. (2010) GIP: No Longer the Neglected Incretin Twin? Sci Transl Med. 2(49):49ps47 http://www.ncbi.nlm.nih.gov/pubmed/20844284

Vesterhus M., Raeder H., Kurpad A. J., Kawamori D., Molven A., Kulkarni R. N., Kahn C. R., Njolstad P. R. (2010) Pancreatic Function in Carboxyl-Ester Lipase Knockout Mice. Pancreatology. 10(4):467-476. http://www.ncbi.nlm.nih.gov/pubmed/20720448

Reiner, T., Kohler, R. H., Liew, C. W., Hill, J., Gaglia, J., Kulkarni, R. N., and Weissleder, R. (2010) Near-Infrared Fluorescent Probe for Imaging of Pancreatic beta-cells. Bioconjugate Chem 21(7):1362-8. http://www.ncbi.nlm.nih.gov/pubmed/20583828

Liew, C. W., Bochenski, J., Kawamori, D., Hu, J., Leech, C. A., Wanic, K., Malecki, M., Warram, J. H., Qi, L., Krolewski, A. J., and Kulkarni, R. N. (2010) The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta-cells. J Clin Invest 120(8):2876-88. http://www.ncbi.nlm.nih.gov/pubmed/20592469

Cheng, K., Ho, K., Stokes, R., Scott, C., Mei Lau, S., Hawthorne, W. J., Oonnell, P. J., Loudovaris, T., Kay, T. W., Kulkarni, R. N., Okada, T., Wang, X., Yim, S., Shah, Y., Grey, S. T., Biankin, A. V., Kench, J. G., Laybutt, D. R., Gonzalez, F. J., Kahn, C. R., and Gunton, J. E. (2010) Hypoxia-inducible factor-1alpha regulates beta-cell function in mice and in human islets. J Clin Invest 120(6): 2171-83. http://www.ncbi.nlm.nih.gov/pubmed/20440072

Kawamori, D., Welters, H. J., and Kulkarni, R. N. (2010) Molecular pathways underlying the pathogenesis of pancreatic alpha-cell dysfunction. The Islets of Langerhans, Advances in Experimental Medicine and Biology 654: 421-45. Review http://www.ncbi.nlm.nih.gov/pubmed/20217508

Bouche, C., Lopez, X.,Fleischman, A., Cypess, A. M., O?hea, S., Stefanovski, D., Bergman, R. N., Rogatsky, E., Stein, D. T., Kahn, C. R., Kulkarni, R. N., and Goldfine, A. B. (2010) Insulin enhances glucose-stimulated insulin secretion in healthy humans. Proc Natl Acad Sci USA 107(10): 4770-5. http://www.ncbi.nlm.nih.gov/pubmed/20176932

Cornu, M., Modi, H., Kawamori, D., Kulkarni, R. N., Joffraud, M., and Thorens, B. (2010) Glucagon-like peptide-1 (GLP-1) increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor (IGF-1R) expression. J Biol Chem 285(14):10538-45. http://www.ncbi.nlm.nih.gov/pubmed/20145256

Georgia, S., Hinault, C., Kawamori, D., Hu, J., Meyer, J., Kanji, M., Bhushan, A., and Kulkarni, R. N. (2010) Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents. Diabetes 59(4):987-96. http://www.ncbi.nlm.nih.gov/pubmed/20103709

Robertson, S., Ishida-Takahashi, R., Tawara, I., Hu, J., Patterson, C. M., Jones, J. C., Kulkarni, R. N., and Myers, M. G. Jr. (2010) Insufficiency of Jak2-autonomous leptin receptor signals for most physiologic leptin actions. Diabetes 59(4):782-90. http://www.ncbi.nlm.nih.gov/pubmed/20068132

Zhang, Z., Liew, C. W., Handy, D. E., Zhang, Y., Leoold, J. A., Hu, J., Guo, L., Loscalzo, J., Kulkarni, R. N., and Stanton, R. C. (2010) High glucose inhibits glucose-6-phosphate dehydrogenase leading to increased oxidative stress and beta cell apoptosis. FASEB J 24(5):1497-505. http://www.ncbi.nlm.nih.gov/pubmed/20032314

 

2009

Liu, S., Okada, T., Assmann, A., Soto, J., Liew, C. W., Bugger, H., Shirihai, O., Abel, E. D., and Kulkarni, R. N. (2009) Insulin signaling regulates mitochondrial function in pancreatic beta-cells. PLoS One 24;4(11): e7983 http://www.ncbi.nlm.nih.gov/pubmed/19956695

Kawamori, D. and Kulkarni, R. N. (2009) Insulin modulation of glucagon secretion: The role of insulin and other factors in the regulation of glucagon secretion. Islets 1(3):276-9 http://www.ncbi.nlm.nih.gov/pubmed/21099284

Zhou, J. Y., Petritis, B. O., Petritis, K., Norbeck, A. D., Weitz, K. K., Moore, R. J., Camp, D. G., Kulkarni, R. N., Smith, R. D., and Qian, W. J. (2009) Mouse-Specific Tandem IgY7-SuperMix Immunoaffinity Separations for Improved LC-MS/MS Coverage of the Plasma Proteome. J Proteome Res. 8: 5387-95. http://www.ncbi.nlm.nih.gov/pubmed/19722698

Liew, C. W., Holman, A., and Kulkarni, R. N. (2009) The roles of telomeres and telomerase in beta-cell regeneration. Diabetes Obes Metab 11, Suppl 4:21-9.

Borowiec, M., Liew, C. W., Thompson, R., Boonyasrisawat, W., Hu, J., Mlynarski, W. M., El Khattabi, I., Kim, S. H., Marselli, L., Rich, S. S., Krolewski, A. S., Bonner-Weir, S., Sharma, A., Sale, M., Mychaleckyj, J. C., Kulkarni, R. N., and Doria, A. (2009) Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Proc Natl Acad Sci U S A. 106, 14460-5. http://www.ncbi.nlm.nih.gov/pubmed/19667185

Kulkarni, R. N. (2009) Uncoupling modifier genes from uncoupling protein 2 in pancreatic beta-cells. Endocrinology. 150, 2994-6 http://www.ncbi.nlm.nih.gov/pubmed/19549885

Kawamori, D., Kurpad, A. J., Hu, J., Liew, C. W., Shih, J. L., Ford, E. L., Herrera, P. L., Polonsky, K. S., McGuinness, O. P., and Kulkarni, R. N. (2009) Insulin signaling in alpha-cells modulates glucagon secretion in vivo. Cell Metabolism Apr;9(4):350-61. http://www.ncbi.nlm.nih.gov/pubmed/19356716

Assmann, A., Ueki, K., Winnay, J. N., and Kulkarni, R. N. (2009) Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate-2. Mol Cell Biol 29:3219-28 http://www.ncbi.nlm.nih.gov/pubmed/19273608

Torii, S., Saito, N., Kawano, A., Hou, N., Ueki, K., Kulkarni, R. N., Takeuchi, T. (2009) Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta cell growth. Diabetes 58:682-92 http://www.ncbi.nlm.nih.gov/pubmed/19073770

Assmann, A., Hinault, C., and Kulkarni, R. N. (2009) Growth factor control of pancreatic islet regeneration and function. Pediatric Diabetes 10:14-32. http://www.ncbi.nlm.nih.gov/pubmed/18828795

Hisanaga, E., Nagasawa, M., Ueki, K., Kulkarni, R. N.,  Mori, M. M. and Kojima. I. (2009) Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells. Diabetes 58:174-84 http://www.ncbi.nlm.nih.gov/pubmed/18984736

 

2008

Welters, H. J. and Kulkarni, R. N. (2008) Wnt signaling and type 2 diabetes. Trends Endocrinol Metab 19:349-55. http://www.ncbi.nlm.nih.gov/pubmed/18926717

Tseng, Y-H., Kokkotou, E., Huang, T. L., Taniguchi, C. M., Tran, T. T., Suzuki, R., Schulz, T. J.,  Espinoza, D. O., Winnay, J. N., Yamomoto, Y., Ahrens, M. J., Dudley, A. T., Norris, A. W., Kulkarni, R. N., and Kahn, C. R (2008) Novel role of bone morphogenetic protein-7 in brown adipogenesis and energy expenditure. Nature 454, 1000-4. http://www.ncbi.nlm.nih.gov/pubmed/18719589

Deangelis, A. M., Heinrich, G., Bowman, T. A., Patel, P. R., Dai, T., Lee, S-J., Hong, E-G., Jung, D-Y., Assmann, A., Kulkarni, R. N., Beauchemin, N., Kim, J. K., and Najjar, S. M. (2008) CEACAM1: A Link Between Insulin and Lipid Metabolism. Diabetes 57, 2296-303. http://www.ncbi.nlm.nih.gov/pubmed/18544705

Hinault, C., Hu, J., Maier, B. F., Mirmira, R. G., and Kulkarni, R. N. (2008) Differential expression of cell cycle proteins during aging of pancreatic islet cells. Diabet Obes Metab 10, 136-46. http://www.ncbi.nlm.nih.gov/pubmed/18834441

Petyuk, V., Qian, W-J., Hinault, C., Gritsenko, M., Singhal, M., Monroe, M., Camp, D., Kulkarni, R. N. *, and Smith, R. D.* (2008) Characterization of the mouse pancreatic islet proteome and comparative analysis with other mouse tissues. J Proteome Res 7, 3114-26. (*corresponding) http://www.ncbi.nlm.nih.gov/pubmed/18570455


2007

Page, K., DeJardin, S., Kahn, C. R., Kulkarni, R. N., Herold, K., and Inzucchi, S. (2007) Type B insulin resistance syndrome in a hospitalized patient with diabetes mellitus, responsive to immunotherapy. Nat Clin Pract Endocrinol Med. 3, 835-40 http://www.ncbi.nlm.nih.gov/pubmed/18026162

Handschin C., Choi, C. S., Chin, S., Kim, S., Kawamori, D., Kurpad, A. J., Neubauer, N., Hu, J., Liu, F., Maratos-Flier, E., Mooth, V. K., Kim, Y., Kulkarni, R. N., Shulman, G. I., and Spiegelman, B. M. (2007) Abnormal glucose homeostasis in skeletal muscle-specific PGC-1 knockout mice through skeletal muscle-pancreatic b-cell cross-talk. J Clin Invest. 117, 3463-74 http://www.ncbi.nlm.nih.gov/pubmed/17932564

Morioka, T., Asilmaz, E., Hu, J., Dishinger, J. F., Kurpad, A. J., Elias, C. F., Li, H., Elmquist, J. K., Kennedy, R. T., and Kulkarni, R. N. (2007) Disruption of leptin receptor expression in the pancreas directly impacts islet growth and function. J Clin Invest. 117, 2860-8 http://www.ncbi.nlm.nih.gov/pubmed/17909627

Matsumura, K., Chang, BH-J., Fujiyama, M., Chen, W., Kulkarni, R. N., Eguchi, Y., Kimura, H., Kojima, H., and Chan, L. (2007) Aquaporin is a beta-cell protein and regulator of intra-islet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion. Mol Cell Biol. 27, 6026-37 http://www.ncbi.nlm.nih.gov/pubmed/17576812

Kulkarni, R. N. and Kahn, C. R. (2007) Ephs and ephrins keep pancreatic Beta cells connected. Cell. 129, 241-3. http://www.ncbi.nlm.nih.gov/pubmed/17448984

Okada, T., Liew, C. W., Hu, J., Hinault, C., Michael, M. D., Krutzfeldt, J., Yin, C., Holzenberger, M., Stoffel, M., and Kulkarni, R. N. (2007) Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance. Proc Natl Acad Sci U S A. 104, 8977-82. http://www.ncbi.nlm.nih.gov/pubmed/17416680

Pissios, P., Ozcan, U., Kokkotou, E., Okada, T., Liew, C. W., Liu, S., Peters, J. N., Dahlgren, G., Karamchandani, J., Kudva, Y. C., Kurpad, A. J., Kennedy, R. T., Maratos-Flier, E., and Kulkarni, R. N. (2007) Melanin concentrating hormone is a novel regulator of islet function and growth. Diabetes. 56, 311-319. http://www.ncbi.nlm.nih.gov/pubmed/17259374

 

2006

Ueki, K., Okada, T., Hu, J., Liew, C. W., Assmann, A., Dahlgren, G. M., Peters, J. L., Shackman, J. G., Zhang, M., Artner, I., Satin, L. S., Stein, R., Holzenberger, M., Kennedy, R. T., Kahn, C. R., and Kulkarni, R. N. (2006) Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nat Genet 38, 583-588. http://www.ncbi.nlm.nih.gov/pubmed/16642022

Qi, L., Heredia, J. E., Altarejos, J. Y., Screaton, R., Goebel, N., Niessen, S., Macleod, I. X., Liew, C. W., Kulkarni, R. N., Bain, J., Newgard, C., Nelson, M., Evans, R. M., Yates, J., and Montminy, M. (2006) TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science 312, 1763-1766. http://www.ncbi.nlm.nih.gov/pubmed/16794074

Neubauer, N., and Kulkarni, R. N. (2006) Molecular approaches to study control of glucose homeostasis. Ilar J 47, 199-211. http://www.ncbi.nlm.nih.gov/pubmed/16804195

Koh, H. J., Arnolds, D. E., Fujii, N., Tran, T. T., Rogers, M. J., Jessen, N., Li, Y., Liew, C. W., Ho, R. C., Hirshman, M. F., Kulkarni, R. N., Kahn, C. R., and Goodyear, L. J. (2006) Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Mol Cell Biol 26, 8217-8227. http://www.ncbi.nlm.nih.gov/pubmed/16966378

He, Z., Opland, D. M., Way, K. J., Ueki, K., Bodyak, N., Kang, P. M., Izumo, S., Kulkarni, R. N., Wang, B., Liao, R., Kahn, C. R., and King, G. L. (2006) Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arterioscler Thromb Vasc Biol 26, 787-793. http://www.ncbi.nlm.nih.gov/pubmed/16469952

 

2005

Kulkarni, R. N. (2005) New insights into the roles of insulin/IGF-I in the development and maintenance of beta-cell mass. Rev Endocr Metab Disord 6, 199-210. http://www.ncbi.nlm.nih.gov/pubmed/16151624

Hennige, A. M., Ozcan, U., Okada, T., Jhala, U. S., Schubert, M., White, M. F., and Kulkarni, R. N. (2005) Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. Am J Physiol Endocrinol Metab 289, E337-346. http://www.ncbi.nlm.nih.gov/pubmed/15827066

Gunton, J. E., Kulkarni, R. N., Yim, S., Okada, T., Hawthorne, W. J., Tseng, Y. H., Roberson, R. S., Ricordi, C., O'Connell, P. J., Gonzalez, F. J., and Kahn, C. R. (2005) Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell 122, 337-349. http://www.ncbi.nlm.nih.gov/pubmed/16096055

Bates, S. H., Kulkarni, R. N., Seifert, M., and Myers, M. G., Jr. (2005) Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis. Cell Metab 1, 169-178. http://www.ncbi.nlm.nih.gov/pubmed/16054060

 

2004


Otani, K., Kulkarni, R. N., Baldwin, A. C., Krutzfeldt, J., Ueki, K., Stoffel, M., Kahn, C. R., and Polonsky, K. S. (2004) Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am J Physiol Endocrinol Metab 286, E41-49. http://www.ncbi.nlm.nih.gov/pubmed/14519599

Kulkarni, R. N. (2004) The islet beta-cell. Int J Biochem Cell Biol 36, 365-371. http://www.ncbi.nlm.nih.gov/pubmed/14687913

Kulkarni, R. N., and Kahn, C. R. (2004) Molecular biology. HNFs--linking the liver and pancreatic islets in diabetes. Science 303, 1311-1312. http://www.ncbi.nlm.nih.gov/pubmed/14988544

Kulkarni, R. N., Roper, M. G., Dahlgren, G., Shih, D. Q., Kauri, L. M., Peters, J. L., Stoffel, M., and Kennedy, R. T. (2004) Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3. Diabetes 53, 1517-1525. http://www.ncbi.nlm.nih.gov/pubmed/15161756

Kulkarni, R. N., Jhala, U. S., Winnay, J. N., Krajewski, S., Montminy, M., and Kahn, C. R. (2004) PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest 114, 828-836. http://www.ncbi.nlm.nih.gov/pubmed/15372107

Goren, H. J., Kulkarni, R. N., and Kahn, C. R. (2004) Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1. Endocrinology 145, 3307-3323. http://www.ncbi.nlm.nih.gov/pubmed/15044376

 

2003


Rosen, E. D., Kulkarni, R. N., Sarraf, P., Ozcan, U., Okada, T., Hsu, C. H., Eisenman, D., Magnuson, M. A., Gonzalez, F. J., Kahn, C. R., and Spiegelman, B. M. (2003) Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol 23, 7222-7229. http://www.ncbi.nlm.nih.gov/pubmed/14517292

Kulkarni, R. N., and Zisman, A. (2003) Lessons for human diabetes from experimental mouse models. Curr Diab Rep 3, 168-175. http://www.ncbi.nlm.nih.gov/pubmed/12728643

Kulkarni, R. N., Almind, K., Goren, H. J., Winnay, J. N., Ueki, K., Okada, T., and Kahn, C. R. (2003) Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice. Diabetes 52, 1528-1534. http://www.ncbi.nlm.nih.gov/pubmed/12765966

Jiang, Z. Y., He, Z., King, B. L., Kuroki, T., Opland, D. M., Suzuma, K., Suzuma, I., Ueki, K., Kulkarni, R. N., Kahn, C. R., and King, G. L. (2003) Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis. J Biol Chem 278, 31964-31971. http://www.ncbi.nlm.nih.gov/pubmed/12775712

Jhala, U. S., Canettieri, G., Screaton, R. A., Kulkarni, R. N., Krajewski, S., Reed, J., Walker, J., Lin, X., White, M., and Montminy, M. (2003) cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev 17, 1575-1580. http://www.ncbi.nlm.nih.gov/pubmed/12842910

Hennige, A. M., Burks, D. J., Ozcan, U., Kulkarni, R. N., Ye, J., Park, S., Schubert, M., Fisher, T. L., Dow, M. A., Leshan, R., Zakaria, M., Mossa-Basha, M., and White, M. F. (2003) Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. J Clin Invest 112, 1521-1532. http://www.ncbi.nlm.nih.gov/pubmed/14617753

Du, K., Herzig, S., Kulkarni, R. N., and Montminy, M. (2003) TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 300, 1574-1577. http://www.ncbi.nlm.nih.gov/pubmed/12791994

Almind, K., Kulkarni, R. N., Lannon, S. M., and Kahn, C. R. (2003) Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance. Diabetes 52, 1535-1543. http://www.ncbi.nlm.nih.gov/pubmed/12765967

 

2002


Roper, M. G., Qian, W. J., Zhang, B. B., Kulkarni, R. N., Kahn, C. R., and Kennedy, R. T. (2002) Effect of the insulin mimetic L-783,281 on intracellular Ca2+ and insulin secretion from pancreatic beta-cells. Diabetes 51 Suppl 1, S43-49. http://www.ncbi.nlm.nih.gov/pubmed/11815457

Mauvais-Jarvis, F., Kulkarni, R. N., and Kahn, C. R. (2002) Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance. Clin Endocrinol (Oxf) 57, 1-9. http://www.ncbi.nlm.nih.gov/pubmed/12100063

Laustsen, P. G., Michael, M. D., Crute, B. E., Cohen, S. E., Ueki, K., Kulkarni, R. N., Keller, S. R., Lienhard, G. E., and Kahn, C. R. (2002) Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice. Genes Dev 16, 3213-3222. http://www.ncbi.nlm.nih.gov/pubmed/12502742

Kulkarni, R. N., Holzenberger, M., Shih, D. Q., Ozcan, U., Stoffel, M., Magnuson, M. A., and Kahn, C. R. (2002) beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat Genet 31, 111-115. http://www.ncbi.nlm.nih.gov/pubmed/11923875

Kulkarni, R. N. (2002) Receptors for insulin and insulin-like growth factor-1 and insulin receptor substrate-1 mediate pathways that regulate islet function. Biochem Soc Trans 30, 317-322. http://www.ncbi.nlm.nih.gov/pubmed/12023872

Kulkarni, R. N., and Okada, T. (2002) Tissue-specific targeting of the insulin receptor gene. Endocrine 19, 257-266. http://www.ncbi.nlm.nih.gov/pubmed/12624425

 

2001


Leibiger, B., Leibiger, I. B., Moede, T., Kemper, S., Kulkarni, R. N., Kahn, C. R., de Vargas, L. M., and Berggren, P. O. (2001) Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells. Mol Cell 7, 559-570. http://www.ncbi.nlm.nih.gov/pubmed/11463381

Flier, S. N., Kulkarni, R. N., and Kahn, C. R. (2001) Evidence for a circulating islet cell growth factor in insulin-resistant states. Proc Natl Acad Sci U S A 98, 7475-7480. http://www.ncbi.nlm.nih.gov/pubmed/11404474

 

2000


Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A., and Kahn, C. R. (2000) Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell 6, 87-97. http://www.ncbi.nlm.nih.gov/pubmed/10949030

Mauvais-Jarvis, F., Virkamaki, A., Michael, M. D., Winnay, J. N., Zisman, A., Kulkarni, R. N., and Kahn, C. R. (2000) A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes. Diabetes 49, 2126-2134. http://www.ncbi.nlm.nih.gov/pubmed/11118016

Kulkarni, R. N., Wang, Z. L., Wang, R. M., Smith, D. M., Ghatei, M. A., and Bloom, S. R. (2000) Glibenclamide but not other sulphonylureas stimulates release of neuropeptide Y from perifused rat islets and hamster insulinoma cells. J Endocrinol 165, 509-518. http://www.ncbi.nlm.nih.gov/pubmed/10810315

Kahn, C. R., Bruning, J. C., Michael, M. D., and Kulkarni, R. N. (2000) Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes mellitus. J Pediatr Endocrinol Metab 13 Suppl 6, 1377-1384. http://www.ncbi.nlm.nih.gov/pubmed/11202213

Aspinwall, C. A., Qian, W. J., Roper, M. G., Kulkarni, R. N., Kahn, C. R., and Kennedy, R. T. (2000) Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta -cells. J Biol Chem 275, 22331-22338. http://www.ncbi.nlm.nih.gov/pubmed/10764813

 

1999


Kulkarni, R. N., Bruning, J. C., Winnay, J. N., Postic, C., Magnuson, M. A., and Kahn, C. R. (1999) Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96, 329-339. http://www.ncbi.nlm.nih.gov/pubmed/10025399

Kulkarni, R. N., Winnay, J. N., Daniels, M., Bruning, J. C., Flier, S. N., Hanahan, D., and Kahn, C. R. (1999) Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. J Clin Invest 104, R69-75. http://www.ncbi.nlm.nih.gov/pubmed/10606633