President & CEOOfficers of the CorporationBoard of TrusteesFoundation BoardLeadership CouncilAbout Joslin ResearchAdvocacy & Gov't AffairsHistory
Newly DiagnosedManaging DiabetesChildhood DiabetesNutritionExerciseOnline Diabetes ClassesDiscussion BoardsJoslin Clinical ResearchInfo for Healthcare ProfessionalsJoslin Clinical Guidelines
Make an AppointmentmyJoslin | Patient PortalAdult ClinicYoung Adult Transition CarePediatricsEye CareWeight Management ProgramsDO ITMental Health & CounselingReferring PhysiciansBillingAfrican American ProgramsAsian ClinicLatino Diabetes InitiativeAbout Joslin ResearchVolunteer for Clinical Research StudiesInfo for Healthcare ProfessionalsClinical Guidelines
Directory of Joslin InvestigatorsDiabetes Research Center Alumni ConnectionVolunteer for Clinical Research Studies
Media RelationsNews ReleasesInside JoslinSocial Media
Affiliated CentersPharma & DeviceCorporate EducationPublicationsProfessional EducationInternationalCause MarketingHealthcare ProfessionalsCommercialization and VenturesJoslin Institute for Technology Translation (JITT)
Give NowHigh Hopes FundWays to GivePlanned GivingEventsGet InvolvedCorporate & Foundation SupportOur DonorsDevelopment Team

Diane Mathis, Ph.D.

Our lab works in the broad fields of T cell differentiation and tolerance/autoimmunity, translating mechanistic studies on mouse models to normal and diseased humans. Studies on T cell differentiation focus on maturation and selection of the T cell repertoire in the thymus, and on cellular and molecular influences on the “flavor” of T cell responses in the periphery. Studies on autoimmunity explore the immunological mechanisms of type-1 diabetes, rheumatoid arthritis and APECED, in particular central and peripheral mechanisms of T cell tolerance. Major questions tackled are what initiates these diseases, how is their progression regulated, what are the final effector mechanisms, and how do genetic and environmental factors impact on disease unfolding. Current foci include: the Aire transcriptional regulatory molecule, Foxp3-expressing Treg cells, and gut microbiota. The application of computational and bioinformatic strategies to these and other issues is one of the lab’s particular strengths. Lastly, we have been engaged in a long-term collaborative effort to develop and apply novel whole-mouse and intravital imaging strategies to immunological problems, especially as concerns mechanisms of autoimmunity.

Page last updated: October 25, 2014