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Studies for People with Type 1 Diabetes (insulin-dependent or IDDM)

Safety and Efficacy of Imatinib (Gleevec) for Preserving Beta-cell Function in New-onset Type 1 Diabetes Mellitus. The GleeT1D Study.

Description: GleeT1D is a study where researchers want to test if Gleevec® (imatinib mesylate) may be of benefit in slowing the body’s destruction of beta cells when given to individuals recently diagnosed with Type 1 Diabetes (T1D). The goal of this study is to preserve beta cells so that the body can continue to produce some of its own insulin. Even when insulin injections are needed, it is believed that insulin produced by the body can improve overall blood sugar control, make daily management of T1D easier, and may reduce the risk of long-term complications. Participation in the GleeT1D study will last up to 2 years and will involve taking pills (either Gleevec® or a placebo) once a day for 6 months and periodically coming in to Joslin Diabetes Center for follow up visits and lab tests.

Recruitment: Seeking individuals who have been diagnosed with type 1 diabetes less than 3 months ago and are 18 to 45 years of age

Contact: Brittany Resnick at 617-309-4148 or brittany.resnick@joslin.harvard.edu

(CHS# 2014-32)

Validation of Protective Markers in those with 30-49 years of Type 1 Diabetes (Resistor Study)

Description: The purpose of this study is to identify and confirm substances that are associated with protection from complications of type 1 diabetes by studying individuals who have not developed severe eye and/or kidney disease after a diabetes duration of 30–49 years. The study aims to show that factors associated with protection from complications those with 50 or more years of type 1 diabetes may also be protect from complications in populations with shorter diabetes durations and higher levels of HbA1c.

Recruitment:Patients with 30-49 years of type 1 diabetes with HbA1c ≥ 7.5%, who do not have proliferative eye disease  or who do not have kidney disease (eGFR > 60 ml/min/1.73 m2).

Contact: stephanie d’eon at (617) 309-4532 or stephanie.d'eon@joslin.harvard.edu

(CHS# 2013-07)

Study to prevent kidney disease in Type 1 Diabetes

Description: The goal of this study is to investigate whether a medication called allopurinol may help prevent the loss of kidney function that sometimes occurs among people with type 1 diabetes. The study involves 17 visits to the Joslin Diabetes Center over a 3 year period and taking two allopurinol or inactive pills twice a day during this period. Study procedures will include blood tests, urine tests, and other medical tests to monitor kidney function. All medical procedures and medications are at no cost to the participant. Monetary compensation is available.

Recruitment: Eligible patients aged 18-65 who: 1) Have been diagnosed with type 1 diabetes before age 35, 2) Have had diabetes for more than 8 years, and 3) Have been told by their physician that they have kidney problems related to their diabetes, such as increased amounts of proteins in their urine.

Contact: Ana Kay Thompson or Benjamin Flagg at (617) 309-4760 or email at PERLstudy@joslin.harvard.edu

(CHS #2013-19)

TrialNet Natural History Study for the Prevention of Type 1 Diabetes

Description: The study aims to identify youth and adults at risk for type 1 diabetes by testing for diabetes-related antibodies in relatives of people with type 1 diabetes.  It involves a single blood test.  People who test positive will be eligible for further testing and may be eligible to participate in prevention trials.

Recruitment: Parents, children, & siblings, ages 1-45, and cousins, grandchildren, nieces, & nephews, ages 1-20, of people with type 1 diabetes.

Contact: Sarah Szubowicz at (617) 309-4493 or sarah.szubowicz@joslin.harvard.edu

(CHS #03-33)

Monitoring Autoimmunity in Diabetes

Description: The purpose of the "Monitoring Autoimmunity in Diabetes" study is to look at changes in the body that may occur with the development of type 1 diabetes. The samples taken as part of this study will be used to look at various genes, cells, and factors, which may be associated with type 1 diabetes and the immune system. These will be used to study why some people are at higher risk for developing diabetes and what happens to the immune system with the development of the disease. Participants may also qualify and be asked to participate in a separate clinical study that uses a novel magnetic resonance imaging (MRI) technique to noninvasively image insulitis (the destructive process in the pancreas that leads to loss of insulin production).

Recruitment: Seeking controls (no history of type 1 diabetes) and persons recently diagnosed with type 1 diabetes (within last 6 months). Must be 18 years or older.

Contact: Sarah Szubowicz at (617) 309-4493 or sarah.szubowicz@joslin.harvard.edu

(CHS #2010-27)

Fast Progression to Diabetic Complications (Progressor Study)

Description: The purpose of this study is to associate identified factors with the protection from the progression of eye and kidney complications related to type 1 diabetes. These will be studied in individuals with type 1 diabetes who have experienced rapid progression to severe diabetic retinopathy and/or diabetic nephropathy, despite good glycemic control. By studying these factors, researchers can subsequently confirm and potentially identify other factors that provide protection from eye and kidney complications.

Recruitment:Patients with type 1 diabetes with HbA1c ≤7.5%, who have progressed to severe non-proliferative diabetic retinopathy in 15 years or less, or to diabetic nephropathy (eGFR <60 ml/min/1.73 m2) within 20 years.

Contact: Stephanie D’Eon at (617) 309-4532 or stephanie.d'eon@joslin.harvard.edu

(CHS# 2013-03)

Page last updated: December 19, 2014