President & CEOOfficers of the CorporationBoard of TrusteesFoundation BoardLeadership CouncilAbout Joslin ResearchAdvocacy & Gov't AffairsHistory
Newly DiagnosedManaging DiabetesChildhood DiabetesNutritionExerciseOnline Diabetes ClassesDiscussion BoardsJoslin Clinical ResearchInfo for Healthcare ProfessionalsJoslin Clinical Guidelines
Make an AppointmentmyJoslin | Patient PortalAdult ClinicYoung Adult Transition CarePediatricsEye CareWeight Management ProgramsDO ITMental Health & CounselingReferring PhysiciansBillingAfrican American ProgramsAsian ClinicLatino Diabetes InitiativeAbout Joslin ResearchVolunteer for Clinical Research StudiesInfo for Healthcare ProfessionalsClinical Guidelines
Directory of Joslin InvestigatorsDiabetes Research Center Alumni ConnectionVolunteer for Clinical Research Studies
Media RelationsNews ReleasesInside JoslinSocial Media
Affiliated CentersPharma & DeviceCorporate EducationPublicationsProfessional EducationInternationalCause MarketingHealthcare ProfessionalsCommercialization and VenturesJoslin Institute for Technology Translation (JITT)
Give NowHigh Hopes FundWays to GivePlanned GivingEventsGet InvolvedCorporate & Foundation SupportOur DonorsDevelopment Team

Steven E. Shoelson, M.D., Ph.D.

Research Summary

Studies in the Shoelson lab focus on the pathogenesis of diabetes and its complications, and potential new avenues for treatment. More specifically, our lab focuses on potential roles of inflammation in the pathogenesis of diabetes (insulin resistance and β cell dysfunction) and its long term macrovascular (atherosclerosis) and microvascular (neuropathy, retinopathy, nephropathy) complications.  More than 10 years ago we rediscovered an arcane medical literature on the use of salicylate in diabetes, and have since developed this line of investigation to (1) better understand pathogenesis in insulin resistance, impaired β cell function, and T2D, (2) provide leads for pharmacological target identification and validation, and (3) develop potential new treatment strategies for patients with T2D and its microvascular complications. These studies led to our identifying both molecular (e.g. NF-κB) and cellular targets of salicylate, which include circulating monocytes and other elements of both innate and adaptive immune systems. These studies are of direct potential value to both researchers in the field and patients with cardiovascular disease and diabetes.

Page last updated: November 20, 2014