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What is Metaglip?

Metaglip is a combination of two kinds of pills, glipizide and metformin, used to treat type 2 diabetes. It helps keep your blood glucose within target range. Diabetes pills are one tool to help manage your blood glucose, but remember that following a meal plan and doing regular physical exercise are still very important.

How does Metaglip work?

Metaglip works by:

  • Helping the pancreas to produce more insulin
  • Helping the body produce less glucose from the liver

Who should not take Metaglip?

  • People with a history of liver, kidney or heart problems; if you have a history of these disorders, discuss it with your provider.
    People who drink alcohol excessively.
  • People with serious conditions such as a severe infection.
  • Women who are pregnant or planning a pregnancy should tell their provider immediately so that the right medication can be prescribed. The safety of Metaglip in pregnancy is not known.

Guidelines for use:

  • Take Metaglip with meals as directed by your provider.
  • Always talk with your provider before changing your dose of Metaglip.

If you stop taking your Metaglip for any reason, let your provider know.

What should I do if I forget to take my Metaglip dose on time?

  • If you have forgotten to take your dose of Metaglip and it is less than 2 hours from the time when you should have taken it, take your dose of Metaglip.
    If you normally take Metaglip twice a day (breakfast and dinner) and forget the morning dose, take the next dose as scheduled. DO NOT ‘DOUBLE’ THE DOSE.
  • If you forget to take your Metaglip for an entire day, DO NOT ‘DOUBLE’ THE DOSE THE NEXT DAY, just resume taking your Metaglip as usual.

What are the side effects of Metaglip?

Minor Side Effects

Low blood glucose (hypoglycemia) is the most common side effect. Be sure to ask your provider how to treat a low blood glucose.

  • Stomach upset, nausea or diarrhea
  • Skin reaction (rash)
  • Dark urine
  • Increased sensitivity to the sun

Major Side Effects

The most serious side effect is lactic acidosis. Lactic acidosis is a rare but serious medical problem that, if left untreated, may be life threatening. If you have severe nausea, bloating, lack of appetite, difficulty breathing or muscle aches, you need to call your provider right away. Note:your provider should check your kidney and liver function tests regularly to make sure that the medication is still safe to use.

Stopping Metaglip


There may be some times when you have to temporarily stop taking Metaglip. Talk with your provider about stopping Metaglip if you are having:

  • A special X-ray procedure that requires an injection of iodine or another type of contrast dye (CT scan, stress test, etc)
  • Severe vomiting, diarrhea or an inability to keep fluids down
  • A surgical procedure

How can I tell if Metaglip is working?


Check your blood glucose at the times specified by your provider. If your glucose or A1C is within target most of the time, the dose is working. If not, review the amount and types of food you have eaten and make sure that you are taking the prescribed dose of Metaglip. If your blood glucose remains high, call your provider as your dose may need to be changed.

Page last updated: July 25, 2014