Research Volunteer Opportunties in Pediatric Clinical Research

The CHEF Study: Cultivating Healthy Environments in Families with Type 1 Diabetes

Description: The CHEF study will explore how family lifestyle behaviors, such as healthy eating and exercise, affect diabetes management in children and teens with type 1 diabetes. The study involves 14 family visits, either in person or by phone, and 2 group sessions over an 18-month period. Many of the visits will be on the same days as regular clinic appointments, but some visits will occur between appointments.

Families in the intervention group will receive educational information about healthy eating. Families in the usual care group will receive this information at the end of the study.

The study also includes completion of surveys and 3-day food records by youth and parents and blood draws for youth. Youth will also wear a masked continuous glucose monitor for 3 days at a time, every 3 months.

Recruiting: Youth with type 1 diabetes receiving care at Joslin, ages 8-16 years, and their parents or legal guardians

Contact: Brittany Ryan at 617-309-4523 or brittany.ryan@joslin.harvard.edu

The Tolerance Study

Description: This study is trying to help us better understand what causes type 1 diabetes to help find new ways to prevent or reverse the disease. The study is being done with researchers at Harvard Medical School and is funded by the Juvenile Diabetes Research Foundation.

The study visit includes the completion of questionnaires and a blood draw.

Recruiting: Individuals, ages 18 years and older, both with and without type 1 diabetes

Contact: Roxanne Phillips at 617-309-2481 or roxanne.phillips@joslin.harvard.edu

Alpha-1 Antitrypsin Injections in Recent-Onset Type 1 Diabetes

Description: This study is looking to see if 12 intravenous infusions of a protein called alpha-1 antitrypsin (AAT) will help people with newly diagnosed type 1 diabetes continue to make some of their own insulin.

In this study, the investigators are looking at the progression of diabetes in people who receive AAT infusions compared to those who get placebo infusions (infusions that look the same but have no AAT). The study involves 22 visits over 2 years.

Recruiting: Age 8-35, diagnosed within 3 months prior to the first infusion. 

Contact: Hui H Zhang, RN, Ph.D at 617-309-4739 or  hui.zhang@joslin.harvard.edu

CGM improve study

Description: The purpose of this study is to find out how to make it easier for children and teens with type 1 diabetes to use continuous glucose monitors (CGM) over a long period of time.

The study involves 12 visits over a 24-month period with additional phone contacts between visits. The extra three visits occur during the first six months of the study: the rest of the visits will occur at routine clinic visits.

Families randomized to the intervention group will receive a family based behavioral intervention providing support and education regarding use of the CGM. Families in the usual care group will receive this information at the end of the study.

Youth in both groups will wear a CGM device throughout the study. Families will be asked to complete surveys at various intervals over the course of the study and labwork will be collected for the youth in the study.

Recruiting: Children and teens, ages 8-17 years, who have had type 1 diabetes for at least 1 year and who are receiving care at Joslin and their parents or legal guardians

Contact: Emily Fisher at 617-309-4644 or Emily.fisher@joslin.harvard.edu

Type 1 Diabetes Risk Assessment
The Natural History Study - TrialNet

Description: This study aims to identify youth and adults at risk for type 1 diabetes by testing for diabetes-related antibodies in relatives of people with type 1 diabetes. It involves a single blood test. People who test positive will be eligible for further testing and may be eligible to participate in prevention trials.

Recruiting: Parents, children, & siblings, ages 1-45, and cousins, grandchildren, nieces, & nephews, ages 1-20, of people with type 1 diabetes

Contact: Heyam Jalahej at 617-309-2524 or heyam.jalahej@joslin.harvard.edu