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Studies for People with Type 1 Diabetes (insulin-dependent or IDDM)

Study to prevent kidney disease in Type 1 Diabetes

Description: The goal of this study is to investigate whether a medication caled allopurinol may help prevent the loss of kidney function that sometimes occurs among people with type 1 diabetes. The study involves periodic visits to Joslin Diabetes Center over a 2 year period and taking two allopurinol or inactive pills twice a day during this period. Study procedures will include blood tests, urine tests, and other medical tests to monitor kidney function. All study-related medical procedures and medications are at no cost to the participant. Monetary compensation is available.

Recruitment: Eligible patients aged 18-60 who: 1) Have been diagnosed with type 1 diabetes before age 35, 2) Have had diabetes for more than 5 years, and 3) Have been told by their physician that they have kidney problems related to their diabetes, such as increased amounts of proteins in their urine.

Contact: If you are interested in participating contact study coordinators, Marcia Cecilia Griggs at (617)309-4760 or Taneisha Vilma at (617) 309-4172. Email at kidney.pilot@joslin.harvard.edu

(CHS #2012-02)

TrialNet Natural History Study for the Prevention of Type 1 Diabetes

Description: The study aims to identify youth and adults at risk for type 1 diabetes by testing for diabetes-related antibodies in relatives of people with type 1 diabetes.  It involves a single blood test.  People who test positive will be eligible for further testing and may be eligible to participate in prevention trials.

Recruitment: Parents, children, & siblings, ages 1-45, and cousins, grandchildren, nieces, & nephews, ages 1-20, of people with type 1 diabetes.

Contact: Sarah Szubowicz at (617) 309-4493 or sarah.szubowicz@joslin.harvard.edu

(CHS #03-33)

Monitoring Autoimmunity in Diabetes

Description: The purpose of the "Monitoring Autoimmunity in Diabetes" study is to look at changes in the body that may occur with the development of type 1 diabetes. The samples taken as part of this study will be used to look at various genes, cells, and factors, which may be associated with type 1 diabetes and the immune system. These will be used to study why some people are at higher risk for developing diabetes and what happens to the immune system with the development of the disease. Participants may also qualify and be asked to participate in a separate clinical study that uses a novel magnetic resonance imaging (MRI) technique to noninvasively image insulitis (the destructive process in the pancreas that leads to loss of insulin production).

Recruitment: Seeking controls (no history of type 1 diabetes) and persons recently diagnosed with type 1 diabetes (within last 6 months). Must be 18 years or older.

Contact: Sarah Szubowicz at (617) 309-4493 or sarah.szubowicz@joslin.harvard.edu

(CHS #2010-27)

Volunteers needed in diabetes study

Description: Do you want to contribute to cutting edge research in diabetes? The Joslin Diabetes Center in Boston is conducting a new research study to investigate Induced Pluripotent cells (iPS) in diabetes. Induced pluripotent cells (iPS) are cells that can be grown forever in a laboratory and can become other types of cells. These cells may someday help us to predict who is at risk of developing diabetes, which may lead to a better understanding of the disease process or possible new therapies . 

Recruiting: If you are between 18-70 years of age with or without diabetes you may be eligible to participate in the study. Participants will come to the Joslin Diabetes Center in Boston 1-2 times, complete a health history and have a brief physical exam, give a sample of blood, urine and a skin biopsy, have cells grown in a laboratory from their skin sample indefinitely for future use.Parking will be covered, although there is no other compensation for participating in this study.

Exclusions include: history of bleeding disorders, and history of irregular heart rhythms.

Contact: For more information about this study, please call Julia Ramus at 617-309-4322, or email julia.ramus@joslin.harvard.edu.

(CHS # 08-22)