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Clinical Studies for People Either With or Without Diabetes

Does a nutrient found in beets reduce diabetes risk?

Description: In this clinical research study we are evaluating whether supplementation of a naturally occurring component found in beets and other vegetables and grains reduces diabetes risk. The product we are studying is a modified amino acid that is important in several metabolic pathways and lower in patients with diabetes and cardiovascular risk factors.

Participants will have a glucose tolerance test, commonly used to diagnose type 2 diabetes and if prediabetic will be randomized (like the flip of a coin) to receive the supplement or a placebo. Measurements of insulin sensitivity, liver fat, and blood vessel function will occur before and after 3 months of supplementation, requiring two days and the overnight stay at the beggining and again at the end of the study with two additional morning visits during the study.

Recruiting: We are seeking clinical Research Volunteers with risk factors for type 2 diabetes or prediabetes who are overweight, between 21-70 years of age, who are willing to help us learn about the effects of naturally occurring food substances on cardiometabolic health.

Contact: If you are interested in learning more about the study, please contact Ana Maria Grizales, MD at 617-309-4736 or email ana.grizales@joslin.harvard.edu

CIRT: Cardiovascular Inflammation Reduction Trial

Description: We are seeking study volunteers who have had a heart attack or been diagnosed with coronary heart disease in the last 5 years to join a research study at the Joslin Diabetes Center to study if reducing inflammation with low-dose methotrexate, a very common anti-inflammatory drug, can lower the risk of having future heart attacks, strokes, or dying from heart disease. This study will include taking methotrexate or placebo for around 3 years, and bimonthly visits with blood draws. Compensation for time and parking is provided.

Recruitment: You may be eligible to participate in CIRT if you have had a heart attack or been diagnosed with coronary heart disease in the past 5 years, and you have either diabetes or a condition called “metabolic syndrome”.

Contact: If you are interested in participating, contact the Study Coordinator, Jackie Piper at: (617)-309-4725 or cirt@joslin.harvard.edu

(CHS #2013-06)

 

 

Page last updated: September 26, 2016