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Studies for People Without Diabetes

CIRT: Cardiovascular Inflammation Reduction Trial

Description: We are seeking study volunteers who have had a heart attack or been diagnosed with coronary heart disease in the last 5 years to join a research study at the Joslin Diabetes Center to study if reducing inflammation with low-dose methotrexate, a very common anti-inflammatory drug, can lower the risk of having future heart attacks, strokes, or dying from heart disease. This study will include taking methotrexate or placebo for around 3 years, and bimonthly visits with blood draws. Compensation for time and parking is provided.

Recruitment: You may be eligible to participate in CIRT if you have had a heart attack or been diagnosed with coronary heart disease in the past 5 years, and you have either diabetes or a condition called “metabolic syndrome”.

Contact: If you are interested in participating, contact the Study Coordinator, Jackie Piper at: (617)-309-4725 or

(CHS #2013-06)

TrialNet Natural History Study for the Prevention of Type 1 Diabetes

Description: The study aims to identify youth and adults at risk for type 1 diabetes by testing for diabetes-related antibodies in relatives of people with type 1 diabetes.  It involves a single blood test.  People who test positive will be eligible for further testing and may be eligible to participate in prevention  trials.

Recruitment: Parents, children, & siblings, ages 1-45, and cousins, grandchildren, nieces, & nephews, ages 1-20, of people with type 1 diabetes.

Contact: If you are interested in learning more about the study, please contact Sarah Szubowicz at (617) 309-4493 or

(CHS #03-33)

Gluten Immunity and Autoimmunity in Type 1 Diabetes

Description:The purpose of this study is to determine whether the immune response causing celiac disease is related to the autoimmune response causing type 1 diabetes. The study consists of a Screening part to determine eligibility followed by a Testing part for those who are eligible to participate. In the Screening part, participants will be asked to give a blood sample for tests of diabetes and celiac disease related antibodies, certain genes that may influence susceptibility to these diseases, viruses that can alter immunity and red blood cell count. In the Testing part, eligible participants will be asked to complete a dietary challenge and symptom diary at home, respond to a follow-up phone call and come in for 2 visits. Active participation is expected to take 21 days. Parking validation provided for all visits and compensation is available for participation in the Testing part of the study.

Recruitment:Participants must be 18-50 years-old, have been diagnosed with celiac disease by a small bowel biopsy, have followed a strict gluten-free diet for at least 12 months, with or without type 1 diabetes.

Contact:: If you are interested in participating contact the Study Coordinator, Sarah Szubowicz at: (617)-309-4493 or email

(CHS #2013-11)

Reduce-IT Study

Description: Would you like to participate in a research study to evaluate an investigational medication and its ability to reduce the risk of having a heart attack, stroke, or other cardiovascular events? The Joslin Diabetes Center is conducting the Reduce-It Study to evaluate the effectiveness of this fish oil product. The study involves about 9 visits over approximately five years, willing to not take any omega 3 fatty acid supplements for the duration of the study, fasting for 10 hours prior to study visits and taking study medication or inactive (placebo) pills.

Recruitment:You may be able to participate in this study if you are 45 yrs of age or older, are taking cholesterol lowering medication (statin), have elevated triglycerides and have a history of one or more of the following: diabetes, previous heart attack or stroke and heart disease. Participants will be reimbursed for parking, study related medical examinations and study related laboratory services.

Contact: If you are interested in learning more about the study, please contact Ellen Golden 617-309-2523, or email at

(CHS #2012-20)

Does a nutrient found in beets reduce diabetes risk?

Description: In this clinical research study we are evaluating whether supplementation of a naturally occuring component found in beets and other vegetables and grains reduces diabetes risk. The product we are studying is a modified amino acid that is important in several metabolic pathways and lower in patients with diabetes and cardiovascular risk factors.  Participants will have a glucose tolerance test, commonly used to diagnose type 2 diabetes and if prediabetic will be randomized (like the flip of a coin) to receive the supplement or a placebo. Measurements of insulin sensitivity, liver fat, and blood vessel function will occur before and after 3 months of supplementation, requiring two days and the overnight stay at the beginning and again at the end of the study with two additional morning visits during the study.

Recruiting: We are seeking clinical Research Volunteers with risk factors for type 2 diabetes or prediabetes who are overwheight, between 21-65 years of age, who are willing to help us learn about the effects of naturally occurring food substances on cardimetabolic health.

Contact: If you are interested in learning more about the study, please contact Ana Maria Grizales, MD at 617-309-4736 or email

(CHS #2013-103)




Page last updated: June 29, 2016