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Clinical Studies for People Either With or Without Diabetes

Does a nutrient found in beets reduce diabetes risk?

Description: In this clinical research study we are evaluating whether supplementation of a naturally occurring component found in beets and other vegetables and grains reduces diabetes risk. The product we are studying is a modified amino acid that is important in several metabolic pathways and lower in patients with diabetes and cardiovascular risk factors. Participants will have a glucose tolerance test, commonly used to diagnose type 2 diabetes and if prediabetic will be randomized (like the flip of a coin) to receive the supplement or a placebo. Measurements of insulin sensitivity, liver fat, and blood vessel function will occur before and after 3 months of supplementation, requiring two days and the overnight stay at the beggining and again at the end of the study with two additional morning visits during the study.

Recruiting: We are seeking clinical Research Volunteers with risk factors for type 2 diabetes or prediabetes who are overweight, between 21-65 years of age, who are willing to help us learn about the effects of naturally occurring food substances on cardiometabolic health.

Contact: If you are interested in learning more about the study, please contact Ana Maria Grizales, MD at 617-309-4736 or email

CIRT: Cardiovascular Inflammation Reduction Trial

Description: We are seeking study volunteers who have had a heart attack or been diagnosed with coronary heart disease in the last 5 years to join a research study at the Joslin Diabetes Center to study if reducing inflammation with low-dose methotrexate, a very common anti-inflammatory drug, can lower the risk of having future heart attacks, strokes, or dying from heart disease. This study will include taking methotrexate or placebo for around 3 years, and bimonthly visits with blood draws. Compensation for time and parking is provided.

Recruitment: You may be eligible to participate in CIRT if you have had a heart attack or been diagnosed with coronary heart disease in the past 5 years, and you have either diabetes or a condition called “metabolic syndrome”.

Contact: If you are interested in participating, contact the Study Coordinator, Jackie Piper at: (617)-309-4725 or

(CHS #2013-06)

SUGAR MGH Study: Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans

Description: The SUGAR MGH Research Study will evaluate whether the different genes people inherit change the response to medications that are commonly used to treat type 2 diabetes, metformin and glipizide.  As part of the study participants will be asked to take these medications and will also be given a sugar drink. 

The study involves two visits to the Joslin Diabetes Clinic one week apart, the first visit takes about 5 hours and the second about 3 hours.  Blood will be drawn at both visits.  Participants will receive monetary compensation, a parking voucher and a free meal for each completed visit. 

Recruiting: We are seeking research volunteers over the age of 18 years who have diabetes but are not currently on diabetes medication, and/or who may be at risk for diabetes (for example, risk factors include high or “borderline-high” blood sugars, being overweight, having a history of gestational diabetes (diabetes during pregnancy), being an ethnic minority, or having a first degree relative with type 2 diabetes). 

Contact: If you are interested in learning more about the study, please feel free to contact Lauren DeVita at 617-309-4478 or email at

(CHS #2007-000193)

Gluten Immunity and Autoimmunity in Type 1 Diabetes

Description:The purpose of this study is to determine whether the immune response causing celiac disease is related to the autoimmune response causing type 1 diabetes. The study consists of a Screening part to determine eligibility followed by a Testing part for those who are eligible to participate. In the Screening part, participants will be asked to give a blood sample for tests of diabetes and celiac disease related antibodies, certain genes that may influence susceptibility to these diseases, viruses that can alter immunity and red blood cell count. In the Testing part, eligible participants will be asked to complete a dietary challenge and symptom diary at home, respond to a follow-up phone call and come in for 2 visits. Active participation is expected to take 21 days. Parking validation provided for all visits and compensation is available for participation in the Testing part of the study.

Recruitment:Participants must be 18-50 years-old, have been diagnosed with celiac disease by a small bowel biopsy, have followed a strict gluten-free diet for at least 12 months, with or without type 1 diabetes.

Contact:: If you are interested in participating contact the Study Coordinator, Sarah Szubowicz at: (617)-309-4493 or email

(CHS #2013-11)

Page last updated: March 29, 2015