Dr. Fabricio Simao received his Ph.D. degree from the Federal University of Rio Grande do Sul, Brazil. He trained as a postdoc in the laboratory of Dr. Edward Feener at Joslin. He is currently an Instructor in Medicine at Harvard Medical School and a Research Associate in the Section on Vascular Biology and Complications.
Dr. Simao’s research is currently aimed at characterizing the role of the plasma kallikrein-kinin system on diabetic vascular complications. He is also investigating the effects of diabetes on cerebral hemorrhage and ischemia-induced edema and infarction. Although stroke is a leading cause of death and disability for people with diabetes, the mechanisms that may contribute to the adverse effects of diabetes on the cerebral vasculature remain poorly understood. Studies are ongoing to characterize the role of plasma kallikrein and bradykinin on vascular permeability, edema, and hematoma expansion during stroke in the presence of high blood glucose. Studies are also underway to characterize the role of the kallikrein-kinin system on vascular, glial, and neuron damage during stroke in diabetic rodent models and cell culture models.