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What is Avandament?

Avandamet is a combination of two types of pills Advandia (rosiglitazone) and Glucophage  (metformin) used to treat type 2 diabetes.  It helps keep your blood glucose within target range. Diabetes pills are one tool to help manage your blood glucose, but remember that following a meal plan and doing regular physical exercise are still very important. 

How does Avandamet work?

Avandamet works by:

  • helping your muscles use insulin more effectively
  • decreasing the amount of glucose released by the liver

Who should not take Avandamet

  • People with a history of liver, kidney or heart problems; if you have a history of these disorders, discuss it with your provider.
  • Women who are pregnant or planning a pregnancy should tell their provider immediately so that the right medication can be prescribed.  The safety of Avandamet in pregnancy is not known.

Guidelines for use:

  • Avandamet can be taken with or without food.

  • Always talk with your provider before changing your dose of Avandamet.
  • In some cases this type of pill has been associated with liver problems.  Your provider will check your liver function tests before starting Avandamet and then periodically thereafter.
  • Avandamet may increase the risk of pregnancy in some premenopausal women; available methods of birth control should be discussed with your provider.

What should I do if I forget to take my Avandamet dose on time?

  • If you normally take Avandamet once a day and you forget your dose at the usual time, take it later the same day.
  • If you forget for an entire day, do not “double” the dose the next day, just resume taking your Avandamet as usual.
  • If you normally take Avandamet twice a day and forget a dose, take the next dose as scheduled. Do not ‘double” the dose.

What are the side effects of Avandamet?

Mild Side Effects

  • Backache
  • Fatigue
  • Fluid Retention or Swelling
  • Congestive heart failure
  • Headache
  • Nausea or mild diarrheaSkin reaction
    Increased sensitivity to the sun

Serious Side Effects

The most serious side effect is lactic acidosis, a rare but serious medical problem that, if left untreated, may be life threatening. Severe nausea, vomiting, bloating, decreased appetite, abdominal pain, severe fatigue or dark urine are all symptoms that should be reported to your provider.

Stopping Avandamet

There may be times when you have to temporarily stop taking Avandamet.  Talk with your provider about stopping Avandamet if you are having:

  • A special X-ray procedure that requires an injection of iodine or another type of contrast dye (CT scan, stress test, etc.)
  • Severe vomiting, diarrhea or an inability to keep fluids down.
  • A surgical procedure.

How will I know if Avandamet is working?

Check your blood glucose at the times specified by your provider. If your glucose or A!C is within target most of the time the dose is working. If not, review the amount and types of food you have eaten and make sure that you are taking the prescribed dose of Avandamet. If your blood glucose remains high, call your provider as a change in your dose may be needed.

    Page last updated: January 10, 2013