The purpose of this study is to learn more about the causes of hypoglycemia (low blood sugar).
This study involves coming to the Joslin Diabetes Center for 1 visit. For some participants, there may be an opportunity to take part in a 2nd visit.
At Visit 1 the following will take place:
- Medical history, physical exam, EKG, and laboratory testing.
- A blood sample will be collected for DNA.
- Questionnaires about symptoms and health.
- Providing a stool sample (collected at home) to assess bacteria in the intestine (microbiome).
If participating, Visit 2 involves:
- Following a specific meal plan for 3 days prior to this visit, and arriving fasting.
- Part of the physical examination will be repeated.
- Meal test with a collection of blood samples measuring glucose levels, and a variety of hormones.
- Instructions will be given on glucose monitoring and wearing of a continuous glucose monitoring device for 10 days at home.
- Keeping a log of food, activity, and glucose levels over the same 10 day period while also wearing a FitBit activity tracker. Compensation and parking costs will be provided.
- Ages 18-65
- Individuals who have a diagnosis of low blood sugars and no history of upper gastrointestinal surgery, and no current diagnosis of diabetes or pre-diabetes.
- Individuals who have had gastric bypass and have developed low blood sugars.
- Healthy individuals without a history of surgery (for comparison).
Alexa Puleio at (617) 309-4463 or Hypoglycemiastudy [at] joslin.harvard.edu