*Names in red are current Joslin Investigators. You can view their bio by clicking on the link.
Principal Investigator | Applicant Institution | Dates of Award | Pilot Project Title |
Albert Edge, PhD | Joslin Diabetes Center | 1986-87 | Studies on carbohydrates of the insulin receptor |
Richard Jackson, MD
| Joslin Diabetes Center | 1986-87 | T cell receptor and MHC genes |
Elefteria Maratos-Flier, MD | Beth Israel Deaconess Med Ctr | 1987-89 | Effect of reovirus infection on gene expression |
Morris White, PhD
| Joslin Diabetes Center | 1987-89 | Relation between the insulin receptor and pp 60src in hepatoma cells |
Steve Rabinowe, MD | Joslin Diabetes Center | 1987-88 | The presence and significance of antiadrenal medullary antibodies in type 1 diabetes mellitus |
Raymonde Dumont (née Herskowitz) M.D. | Joslin Diabetes Center | 1987-88 | Transient hyperglycemia in children |
Joslin Diabetes Center | 1988-90 | Transcriptional control by insulin during myogenesis | |
Masakazu Hattori, MD, PhD | Joslin Diabetes Center | 1988-90 | Islet T-lymphocyte clones of type 1 diabetes patients |
Barry Goldstein,MD, PhD | Joslin Diabetes Center | 1989-91 | Molecular cloning of the rat insulin receptor cDNA |
Barbara Widom, MD | Joslin Diabetes Center | 1989-90 | Mechanism of weight gain during intensive insulin therapy |
Barbara Anderson, William Polonsky PhD, PhD | Joslin Diabetes Center | 1990-91 | Clinical and subclinical eating disorders in female patients with diabetes |
Christopher Rhodes, PhD | Joslin Diabetes Center | 1990-92 | The endopeptidic processing of insulin receptor |
Joslin Diabetes Center | 1991-92 | YMXM motifs, SH2 domains and insulin action | |
Heimo Riedel,PhD | Joslin Diabetes Center | 1991-93 | A genetic screen for receptor-substrate/ligand binding |
Peter Arvan, MD, PhD | Beth Israel Deaconess Med Ctr | 1991-93 | Secretory protein targeting in pancreatic B-cells |
Joslin Diabetes Center | 1992-94 | Genetic dissection of T cell requirements for autoimmune diabetes | |
Joslin Diabetes Center | 1993-95 | The search for genes that cause diabetic embryopathy | |
Joslin Diabetes Center | 1993-95 | Role of vascular endothelial growth factor in diabetic retinopathy | |
Joslin Diabetes Center | 1993-95 | Molecular mechanisms of skeletal muscle insulin resistance | |
Gokhan Hotamisligil, MD, PhD | Harvard School of Public Health | 1995-97 | Role of TNF receptors in obesity and insulin resistance |
Joslin Diabetes Center | 1994-96 | Screening for mutations at the Rad locus, a candidate gene for NIDDM | |
Bentley Cheatham, PhD | Joslin Diabetes Center | 9/1995 - 11/1996 | Role of Rab proteins in Glut4 translocation |
Elefteria Maratos-Flier, MD | Joslin Diabetes Center | 12/1995 - 11/1997 | MCH: A novel regulator of feeding behavior |
Joslin Diabetes Center | 1/1996 - 11/1996 | Pregnancy and diabetic nephropathy in women with IDDM | |
Arun Sharma, PhD | Joslin Diabetes Center | 12/1996 - 11/1998 | Cloning of an insulin gene transcription factor, RIPE3b1 |
Joslin Diabetes Center | 12/1996 - 11/1998 | Novel mechanisms for nutrient regulation of insulin action | |
Martin Myers, MD, PhD | Joslin Diabetes Center | 12/1997 - 11/1999 | Role of Leptin receptor signaling pathways in physiology |
Joslin Diabetes Center | 10/1998 - 9/2000 | Glucose 6-P dehydrogenase and apoptosis in diabetes | |
Christian Bjorbaek, PhD | Beth Israel Deaconess Med Ctr | 10/1999 - 9/2001 | Role of PIAS proteins in Leptin signaling and Leptin resistance |
Deborah Burks, PhD | Joslin Diabetes Center | 10/1999 - 9/2000 | The Role of IRS-2 in endocrine vascular function |
Joslin Diabetes Center | 6/2000 - 5/2002 | Functional complementation of insulin-resistance genes | |
Tihamer Orban, MD | Joslin Diabetes Center | 6/2000 - 5/2002 | Autoantigen vaccination in human type 1 diabetes mellitus |
Lucia Rameh, PhD | Beth Israel Deaconess Med Ctr | 6/2000 - 5/2002 | PIP4kllb role in glucose homeostasis and insulin resistance |
Mark Anderson, MD, PhD | Joslin Diabetes Center | 8/2002 - 8/2003 | Genetic analysis of the AIRE gene in type 1 DM |
Young-Bum Kim, PhD | Beth Israel Deaconess Med Ctr | 8/2002 - 7/2004 | The potential role of the long-form of the leptin receptor in adipocytes. |
Joslin Diabetes Center | 8/2002 - 7/2004 | Role of insulin receptors in islet alpha cell function | |
Gail Adler, MD, PhD | Brigham and Women's Hospital | 8/2003 - 7/2005 | Aldosterone and vascular disease in diabetes. |
Sirano Dhe-Paganon, PhD | Joslin Diabetes Center | 8/2003 - 7/2005 | Structural determination of PKC and drug mapping |
Jongsoon Lee, PhD | Joslin Diabetes Center | 8/2003 - 7/2005 | Role of GSK3b in fat cell differentiation |
Joslin Diabetes Center | 8/2004 - 7/2008 | Executive dysfunction in older diabetic patients | |
Shannon Turley, PhD | Dana-Farber Cancer Institute | 8/2004 - 7/2006 | The capture of dying beta cells by dendritic cells |
Edward Feener, PhD | Joslin Diabetes Center | 3/2005 - 2/2006 | Ion Trap LC-MS/MS quantitation of peptides in vitreous humor |
Timothy Graham, MD, PhD | Beth Israel Deaconess Med Ctr | 8/2005 - 7/2007 | RBP4 & maternal transmission of insulin resistance |
Gail Musen, PhD | Joslin Diabetes Center | 8/2005 - 7/2007 | Functional correlates of gray matter changes in diabetes |
Alan Davidson, PhD | Mass General Hospital | 8/2006 - 7/2008 | Zebrafish model of diabetic nephropathy |
Joslin Diabetes Center | 8/2006 - 7/2008 | Circulating factors in diabetic wound healing | |
Erin Kershaw, MD | Beth Israel Deaconess Med Ctr | 8/2007 - 7/2009 | In Vivo role of adiponutrin in metabolic and energy homeostasis |
Joslin Diabetes Center | 8/2007 - 7/2009 | Role of PKC in diabetic retinopathy | |
Joslin Diabetes Center | 8/2008 - 7/2010 | Why do retinal vessels break through the ILM in PDR? | |
Josef Michael Kurtz, PhD | Mass. General Hospital | 9/2008 - 8/2010 | Characterization of diabetogenic CD4 cells in T1D |
Joslin Diabetes Center | 8/2008 - 7/2010 | Profilin-1 in diet-induced insulin resistance | |
Michael Zeisberg, MD | Beth Israel Deaconess Med Ctr | 8/2008 - 7/2009 | Epigenetics of diabetic nephropathy |
Sudha Biddinger, MD, PhD | Boston Children's Hospital | 8/2009 - 7/2011 | Defects in insulin signaling in the metabolic syndrome |
Ho-Jin Koh, PhD | Joslin Diabetes Center | 8/2009 - 7/2011 | TRB3 modulates glucose-lipid metabolism in skeletal muscle |
Libin Liu, PhD | Joslin Diabetes Center | 8/2009 - 7/2011 | Macrophage Cpe causes obesity in fatty fa/fa mice |
Raul Mostoslavsky, MD, PhD | Mass. General Hospital | 8/2009 - 7/2011 | SIRT6 controls glucose homeostasis |
Joslin Diabetes Center | 8/2010 - 7/2012 | Predicting treatment response in diabetic macular edema | |
Janice Zabolotny, PhD | Beth Israel Deaconess Med Ctr | 8/2010 - 7/2012 | Mechanisms to improve wound healing in diabetes |
Joslin Diabetes Center | 8/2011 - 7/2013 | Imaging Islet-Antigen reactive peripheral T cells | |
Joslin Diabetes Center | 8/2011 - 7/2013 | Regulation of circulating sTNF receptors in diabetes | |
Aaron Cypess, MD, PhD | Joslin Diabetes Center | 1/2013 - 12/2014 | β3-Adrenergic receptor agonists on human brown adipose tissue |
Joslin Diabetes Center | 1/2013 - 12/2014 | How TAGAP variation impacts T cell migration in type 1 diabetes | |
F.M. Fisher, PhD | Beth Israel Deaconess Med Ctr | 1/2014 - 12/2015 | FGF21 induced white adipose tissue browning |
Jongsoon Lee, PhD | Joslin Diabetes Center | 1/2014 - 12/2015 | The role of adipose tissue foam cells in lipid homeostasis and inflammation |
Joslin Diabetes Center | 1/2015 - 12/2016 | Antigen spreading in the initiation of type 1 diabetes | |
Norbert Perrimon, PhD | Harvard Medical School | 1/2015 - 12/2016 | Activin regulation of glucagon action: a novel therapeutic opportunity for type 2 diabetes |
Lijun Sun, PhD | Beth Israel Deaconess Med Ctr | 1/2015 - 12/2016 | Targeting activated mast cells in diabetic foot ulcers |
Joslin Diabetes Center | 1/2016 - 12/2017 | A CRISPR-Cas9 screening for genes regulating pancreatic beta cell proliferation | |
Ashley Vernon, MD | Brigham and Women's Hospital | 1/2016 - 12/2017 | Human adipose tissue microbiome in type 2 diabetes |
Thomas McElrath, MD, PhD | Brigham and Women's Hospital | 1/2017 - 12/2018 | Circulating SerpinB1 and vulnerability to gestational diabetes |
Joslin Diabetes Center | 1/2017 - 12/2018 | Mechanisms of exercise resistance in diabetes | |
Joslin Diabetes Center | 1/2018 - 12/2019 | Induction of beta-cell senescence by high-fat diet and implications for diabetes | |
Eyal Dassau, PhD | Harvard School of Engineering and Applied Sciences | 1/2018 - 12/2019 | Can technology improve self-care in youth with Type-1 Diabetes? |
Stephen Liberles, PhD | Harvard Medical School | 4/2018 - 3/2020 | The impact of vagal nutrient-sensing neurons on systemic metabolism |
Joslin Diabetes Center | 4/2018 - 3/2020 | Hematologic mutations as potential predictors of diabetic complications | |
Sirano Dhe-Paganon, PhD | Dana-Farber Cancer Institute | 5/2019 - 4/2021 | Structural basis of XOR activation in obesity and metabolic syndrome |
Joslin Diabetes Center | 5/2019 - 4/2021 | Designing and testing novel probiotic strategies to curtail glycemic excursion | |
Matthew Lynes, PhD | Joslin Diabetes Center | 7/2020 - 6/2022 | Genetic determinants of 12, 13-diHOME biosynthesis in human obesity |
Linus Tzu-Yen Tsai MD, PhD | Beth Israel Deaconess Med Ctr | 7/2020 - 6/2022 | The role of interferon regulatory factors in tanycytes during HFD-induced inflammation, obesity and glucose dysregulation |
Ismail Sayed, PhD | Beth Israel Deaconess Med Ctr | 4/2021-3/2023 | Effects of novel lipids on on the NLRP3 inflammasome and impact on diabetogenesis in NOD model |
Daniel Zeve, MD, PhD | Boston Children’s Hospital | 4/2021-3/2023 | Use of human enteroids/organoids to induce K and L enteroendocrine cells that appropriately respond to nutrients in vitro and in vivo. |