At Joslin, our researchers are making incredible discoveries that improve diabetes care and move us closer to a cure. Below are selected academic publications led by Joslin faculty issued in recent months.

An antisteatosis response regulated by oleic acid through lipid droplet–mediated ERAD enhancement
Science Advances / Original Research / January 4, 2023
Joslin Authors: Jorge Iván Castillo-Quan, Michael J. Steinbaugh, Laura Paulette Fernández-Cárdenas, Nancy K. Pohl, Ziyun Wu, Feimei Zhu, Natalie Moroz, Veronica Teixeira, Monet S. Bland, Lorenza Moronetti, Magdalena Teufl, T. Keith Blackwell

Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics
PNAS / Original Research / January 3, 2023
Joslin Authors: Juliane Cruz Campos, Takafumi Ogawa, T. Keith Blackwell

Liver-specific FGFR4 knockdown in mice on a HFD increases bile acid synthesis and improves hepatic steatosis
Journal of Lipid Research / Original Research / December 16, 2022
Joslin Authors: Francois Moreau, Bruna Brasil Brunao, Xiang-Yu Liu, Ronald C. Kahn

E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute insulin resistance
Cell Reports / Original Research / October 4, 2022
Joslin Authors: Jun Shirakawa, Giorgio Basile, Megan Fernandez, Dario F. De Jesus, Wei Zhang, Hui Pan, Jonathan M. Dreyfuss, Peng Yi, Rohit N. Kulkarni

Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells
Cell Metabolism / Original Research / October 4, 2022
Joslin Authors: Maria Vamvini, Pasquale Nigro, Nicholas P. Carbone, Michael F. Hirshman, Roeland J.W. Middelbeek, Laurie J. Goodyear


About Joslin Diabetes Center

Joslin Diabetes Center is world-renowned for its deep expertise in diabetes treatment and research. Part of Beth Israel Lahey Health, Joslin is dedicated to finding a cure for diabetes and ensuring that people with diabetes live long, healthy lives. We develop and disseminate innovative patient therapies and scientific discoveries throughout the world.

Joslin is affiliated with Harvard Medical School and one of only 18 NIH-designated Diabetes Research Centers in the United States.


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