Joslin’s basic scientists are discovering critical steps in the development and function of islet cells that produce insulin. They are uncovering how nutrients and physical activity impact our metabolism and how different organs in the body communicate to promote metabolic health. Joslin’s Clinical Research Center (CRC) supports a large number of studies that translate discoveries from the bench to the clinical arena. This center has facilitated the advancement of anti-inflammatory drugs from the basic investigations to NIH-funded, multi-center trial as a treatment for type 2 diabetes. The CRC has also translated the discovery of brown fat in adult humans and to studies of induction of brown fat as a novel therapeutic approach to obesity and type 2 diabetes.
For people with type 1 diabetes, the CRC is testing new treatments to lower autoimmunity and evaluating the use of the artificial pancreas. Our affiliations with Brigham and Women’s Hospital, Beth Israel Deaconess Medical Center, Boston Children’s Hospital, and Harvard Medical School enable Joslin researchers to work with investigators with complementary interests and expertise through such programs as the Harvard Stem Cell Institute, the Clinical Islet Transplantation Program at Harvard Medical School and the Juvenile Diabetes Research Foundation Center on Immunological Tolerance in Type 1 Diabetes. The CRC provides critical infrastructure for these highly collaborative studies.
Interactions that occur within the walls of Joslin often give rise to the important questions that stimulate thinking and drive progress toward cure and prevention of diabetes. Here at Joslin, independent thinking and creativity are valued and supported because we recognize these are the ingredients that lead to greater understanding and discovery. Joslin researchers have the opportunity to exchange ideas and challenge one another in a collegial setting that values creativity and insights that come from diverse training and perspectives.
Scientific progress requires a multidisciplinary team approach like the one found at Joslin Diabetes Center. Joslin’s 50-Year Medalist Study is an example of the unique relationship between clinical researchers at Joslin and their colleagues who specialize in clinical epidemiology, genetics, biochemistry, and cell biology. By studying people who have lived with type 1 diabetes for 50 years, Joslin teams are identifying biomarkers for the development of complications and making surprising discoveries such as the finding that many of the 50-Year Medalists still have insulin-producing islet cells. These observations will help us to develop new approaches to treatment and prevention.
Joslin teams are tackling the complexity of diabetes and its complications with a comprehensive and creative approach. Scientists from Joslin’s Integrative Physiology and Metabolism, Islet Cell and Regenerative Biology, and Immunology Sections are teaming up to solve the mystery of islet failure in type 1 and type 2 diabetes. Our investigators are leveraging databases of biological and psychological data from patients with diabetes, stretching back decades to understand mechanisms that underlie complications and to identify genetic risk factors for diabetes.
Moving Forward As Never Before
To extend the reach of our work, Joslin investigators not only partner with their colleagues down the hall and in the Harvard community, but work with scientists across the globe. We are committed to conquering diabetes in all of its forms and will continue to lead the scientific community on new pathways of discovery in diabetes.