Originally from the Boston area, Jonathan Dreyfuss received his BA from McGill University, his MS from the Department of Statistics and Operations Research at the University of North Carolina – Chapel Hill, and his PhD from the Graduate Program in Bioinformatics at Boston University (BU). At BU, his thesis focused on developing metabolic network modeling algorithms. Between UNC and BU, he was a Bioinformatics Analyst at the Harvard Partners Center for Genetics and Genomics (now called Partners HealthCare Personalized Medicine) under Drs. Peter Park and the late Marco Ramoni. He joined Joslin after his PhD at BU in 2013. He and Dr. Hui Pan provide bioinformatics service to investigators at Joslin on all high-throughput data types, and are available to provide service to those outside Joslin. He is the Associate Director of Biostatistics and Bioinformatics.
At Joslin, his research focuses on developing bioinformatics methodologies and applying them in collaboration with Joslin investigators. He has extended metabolic modeling to the Seahorse Extracellular Flux Analyzer and applied this modeling to identify novel differences in brown vs. white fat. He also developed a network-based pathway analysis algorithm that integrates metabolomics and proteomics, and applied it to identify differences between patients receiving gastric bypass vs. control.
Sato M, Tsuji T, Yang K, Ren X, Dreyfuss JM, Huang TL, Wang CH, Shamsi F, Leiria LO, Lynes MD, Yau KW, Tseng YH. Cell-autonomous light sensitivity via Opsin3 regulates fuel utilization in brown adipocytes. PLoS Biol. 2020 Feb;18(2):e3000630. doi: 10.1371/journal.pbio.3000630. eCollection 2020 Feb. PubMed PMID: 32040503; PubMed Central PMCID: PMC7034924.
Noor N, Cardenas A, Rifas-Shiman SL, Pan H, Dreyfuss JM, Oken E, Hivert MF, James-Todd T, Patti ME, Isganaitis E. Association of Periconception Paternal Body Mass Index With Persistent Changes in DNA Methylation of Offspring in Childhood. JAMA Netw Open. 2019 Dec 2;2(12):e1916777. doi: 10.1001/jamanetworkopen.2019.16777. PubMed PMID: 31880793; PubMed Central PMCID: PMC6991200.
Gordin D, Shah H, Shinjo T, St-Louis R, Qi W, Park K, Paniagua SM, Pober DM, Wu IH, Bahnam V, Brissett MJ, Tinsley LJ, Dreyfuss JM, Pan H, Dong Y, Niewczas MA, Amenta P, Sadowski T, Kannt A, Keenan HA, King GL. Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy. Diabetes Care. 2019 Jul;42(7):1263-1273. doi: 10.2337/dc18-2585. Epub 2019 May 10. PubMed PMID: 31076418; PubMed Central PMCID: PMC6609957.
Mulla CM, Goldfine AB, Dreyfuss JM, Houten S, Pan H, Pober DM, Wewer Albrechtsen NJ, Svane MS, Schmidt JB, Holst JJ, Craig CM, McLaughlin TL, Patti ME. Plasma FGF-19 Levels are Increased in Patients with Post-Bariatric Hypoglycemia. Obes Surg. 2019 Jul;29(7):2092-2099. doi: 10.1007/s11695-019-03845-0. PubMed PMID: 30976983; PubMed Central PMCID: PMC6544487.
Osataphan S, Macchi C, Singhal G, Chimene-Weiss J, Sales V, Kozuka C, Dreyfuss JM, Pan H, Tangcharoenpaisan Y, Morningstar J, Gerszten R, Patti ME. SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and -independent mechanisms. JCI Insight. 2019 Mar 7;4(5). doi: 10.1172/jci.insight.123130. eCollection 2019 Mar 7. PubMed
O'Neill BT, Bhardwaj G, Penniman CM, Krumpoch MT, Suarez Beltran PA, Klaus K, Poro K, Li M, Pan H, Dreyfuss JM, Nair KS, Kahn CR. FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy. Diabetes. 2019 Mar;68(3):556-570. doi: 10.2337/db18-0416. Epub 2018 Dec 6. PubMed PMID: 30523026; PubMed Central PMCID: PMC6385751.
Takahashi H, Alves CRR, Stanford KI, Middelbeek RJW, Pasquale Nigro, Ryan RE, Xue R, Sakaguchi M, Lynes MD, So K, Mul JD, Lee MY, Balan E, Pan H, Dreyfuss JM, Hirshman MF, Azhar M, Hannukainen JC, Nuutila P, Kalliokoski KK, Nielsen S, Pedersen BK, Kahn CR, Tseng YH, Goodyear LJ. TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism. Nat Metab. 2019 Feb;1(2):291-303. doi: 10.1038/s42255-018-0030-7. Epub 2019 Feb 11. PubMed PMID: 31032475; PubMed Central PMCID: PMC6481955.