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The Joslin Clinical Translational Research Center (CTRC) offers a safe, comfortable, and effective environment to conduct outpatient clinical research studies.

The CTRC supports flexible, cost-effective staffing and specialty equipment/services for research studies. With a focus on all forms of diabetes and their complications, the Joslin CTRC provides expertise and facilities that might not otherwise be readily available to individual investigators. The CTRC supports both adult and pediatric studies.

Core Leadership

Lori Laffel
Lori Laffel, MD, MPH
Chief, Pediatric, Adolescent, and Young Adult Section
Section Head, Clinical, Behavioral and Outcomes Research
Senior Investigator
Professor of Pediatrics, Harvard Medical School
Jason Gaglia
Jason Gaglia, MD, MMSc
Staff Physician
Section Head, Clinical, Behavioral and Outcomes Research
Assistant Investigator
Assistant Professor of Medicine, Harvard Medical School
Director of Hood Center for the Prevention of Childhood Diabetes

Services Provided

Operating as a fee for service core, the CTRC provides flexible, cost-effective staffing for research studies. The CTRC provides access to experienced clinical research proceduralists, nurses, clinical research coordinators (CRCs), research assistants (RAs), or specialized technicians, as determined by investigator/study needs. This is particularly helpful for Joslin investigators that are not in a position to offer full-time positions with salary and employment security that such experienced research personnel expect.

Though the Joslin CTRC operates as a fee-for-service core, we offer junior investigators many services at reduced rates or free of charge. Such services may include IRB and regulatory guidance and support, training and education, generation of source documents and case report forms, and assistance with study conduct.

The CTRC is located on the third floor of the Joslin Diabetes Center and consists of nearly eight thousand square feet of space which includes patient reception and waiting area, six examination/treatment rooms, and six infusion/procedures rooms (including a pediatric-focused procedure room).

Exam tables are in the exam rooms for shorter visits, and procedure rooms are equipped with a bed and bariatric recliner for longer studies. There is also a kitchen which provides light nourishment for study subjects, a nursing station with computers, and office/work space for research staff.

Ample space is available for individual meetings with patients to discuss procedures, obtain informed consent, and to perform multiple tests/procedures. Laboratory sample processing facilities include refrigerated and ambient centrifuges, temperature traceable refrigerators, freezers (-20⁰C and -80⁰C), and 37⁰C incubator. Water and dry ice are available. Temporary sample storage is available within the CTRC and sample tracking can be performed via Freezerworks. Access to facilities, equipment, and staff services can be requested via an online system.

Drug Storage and Preparation: The CTRC provides locked, temperature controlled and monitored spaces for study drug storage featuring local and remote alarms and audit-able temperature records. The CTRC also has a USP 797 compliant compounding facility available for use.

Infusion of Drugs and Cellular Products: CTRC staff is familiar with safely performing intravenous infusion of study drugs and cellular products. Available equipment includes IV pumps, syringe pump, specialty emergency medication kits, and automatic defibrillator.

High Performance Rapid Monitoring: Available equipment for high performance rapid monitoring includes YSI glucose and lactate analyzers, and HemoCue glucose analyzers.

Continuous Glucose Monitoring: The CTRC has Medtronic Minimed iPRO5 continuous glucose monitoring systems available for use and also expertise with DexCom and Abbott FreeStyle LibrePro systems.

DEXA: The CTRC has a Discovery Hologic DEXA system and trained technicians to perform adult and pediatric studies including assessment of bone density and body composition.

Clamp Studies: The CTRC has both the equipment and nursing/technical staffing capabilities to perform hyperglycemic clamps as well as hyperinsulinemic-euglycemic clamps.

Muscle and Fat Biopsy: Facilities and training for the safe performance of outpatient muscle and fat biopsies are available.

Metabolic Monitoring: The CTRC can perform both metabolic cardiopulmonary stress testing and indirect calorimetry testing utilizing metabolic carts.

Temperature Regulation: To aid in the study of brown fat, cool flow cooling vests are available.

Ultrasound Capabilities: The CTRC has a Toshiba Power Vision 8000 ultrasound with R-wave gated image capture and high resolution probes. An arm immobilizer is available for flow-mediated dilation studies.

Neuropathy Testing: Specialty equipment available for neuropathy testing includes a Physitemp Thermalert, WR Medical Case IV Computer Aided Sensory Evaluator and Q-Sweat Quantitative Sweat Measurement System.

Exercise Laboratory: The CTRC exercise laboratory can safely perform metabolic assessments (VO2max Encore Calorimeter and Parvo Medics True One 2400 Metabolic Measuring System) with various forms of exercise as well as strength testing (Biodex Isokinetic Strength Testing System).

If any of your research has been supported in full or in part by our core, please acknowledge our NIH/NIDDK grant as follows: "Supported by the Clinical Translational Research Core of NIH P30 DK036836.

Jason Gaglia, M.D., M.M.Sc.
Associate Director, Joslin CTRC
Director Hood Center for Prevention of Childhood Diabetes
Email: Jason.gaglia [at]
Phone: 617-309-4214

Lori Laffel, M.D., M.P.H
Co-Director, Joslin CTRC
Section Head of Clinical Research
Chief of Pediatrics
Email: lori.laffel [at]
Phone: 617-309-3480

Charlene Coneys, R.N.
CTRC Nurse Manager
Email: Charlene.coneys [at]
Phone: 617-309-2749