*Names in red are current Joslin Investigators. You can view their bio by clicking on the link.
 

Principal Investigator

Applicant Institution

Dates of Award

Pilot Project Title

Albert Edge, PhD

Joslin Diabetes Center

1986-87

Studies on carbohydrate of the insulin receptor

Richard Jackson, MD

 

Joslin Diabetes Center

1986-87

T cell receptor and MHC genes

Elefteria Maratos-Flier, MD

Beth Israel Deaconess Med Ctr

1987-89

Effect of reovirus infection on gene expression

Morris White, PhD

 

Joslin Diabetes Center

1987-89

Relation between the insulin receptor and pp 60src in hepatoma cells

Steve Rabinowe, MD

Joslin Diabetes Center

1987-88

The presence and significance of antiadrenal medullary antibodies in type 1 diabetes mellitus

Raymonde Dumont (née Herskowitz) M.D.

Joslin Diabetes Center

1987-88

Transient hyperglycemia in children

Mary Loeken, PhD

Joslin Diabetes Center

1988-90

Transcriptional control by insulin during myogenesis

Masakazu Hattori, MD, PhD

Joslin Diabetes Center

1988-90

Islet T-lymphocyte clones of type 1 diabetes patients

Barry Goldstein,MD, PhD

Joslin Diabetes Center

1989-91

Molecular cloning of the rat insulin receptor cDNA

Barbara Widom, MD

Joslin Diabetes Center

1989-90

Mechanism of weight gain during intensive insulin therapy

Barbara Anderson, William Polonsky PhD, PhD

Joslin Diabetes Center

1990-91

Clinical and subclinical eating disorders in female patients with diabetes

Christopher Rhodes, PhD

Joslin Diabetes Center

1990-92

The endopeptidic processing of insulin receptor

Steven Shoelson, MD, PhD

Joslin Diabetes Center

1991-92

YMXM motifs, SH2 domains and insulin action

Heimo Riedel,PhD

Joslin Diabetes Center

1991-93

A genetic screen for receptor-substrate/ligand binding

Peter Arvan, MD, PhD

Beth Israel Deaconess Med Ctr

1991-93

Secretory protein targeting in pancreatic B-cells

Myra Lipes, MD

Joslin Diabetes Center

1992-94

Genetic dissection of T cell requirements for automimmune diabetes

Mary Loeken, PhD

Joslin Diabetes Center

1993-95

The search for genes that cause diabetic embryopathy

Lloyd-Paul Aiello, MD, PhD

Joslin Diabetes Center

1993-95

Role of vascular endothelial growth factor in diabetic retinopathy

Laurie Goodyear, PhD

Joslin Diabetes Center

1993-95

Molecular mechanisms of skeletal muscle insulin resistance

Gokhan Hotamisligil, MD, PhD

Harvard School of Public Health

1995-97

Role of TNF receptors in obesity and insulin resistance

Alessandro Doria, MD, PhD

Joslin Diabetes Center

1994-96

Screening for mutations at the Rad locus, a candidate gene for NIDDM

Bentley Cheatham, PhD

Joslin Diabetes Center

9/1995 - 11/1996

Role of Rab proteins in Glut4 translocation

Elefteria Maratos-Flier, MD

Joslin Diabetes Center

12/1995 - 11/1997

MCH: A novel regulator of feeding behavior

Lori Laffel, MD

Joslin Diabetes Center

1/1996 - 11/1996

Pregnancy and diabetic nephropathy in women with IDDM

Arun Sharma, PhD

Joslin Diabetes Center

12/1996 - 11/1998

Cloning of an insulin gene transcription factor, RIPE3b1

Mary Elizabeth Patti, MD

Joslin Diabetes Center

12/1996 - 11/1998

Novel mechanisms for nutrient regulation of insulin action

Martin Myers, MD, PhD

Joslin Diabetes Center

12/1997 - 11/1999

Role of Leptin receptor signaling pathyways in physiology

Robert Stanton, MD

Joslin Diabetes Center

10/1998 - 9/2000

Glucose 6-P dehydrogenase and apoptosis in diabetes

Christian Bjorbaek, PhD

Beth Israel Deaconess Med Ctr

10/1999 - 9/2001

Role of PIAS proteins in Leptin signaling and Leptin resistance

Deborah Burks, PhD

Joslin Diabetes Center

10/1999 - 9/2000

The Role of IRS-2 in endocrine vascular function

Alessandro Doria, MD, PhD

Joslin Diabetes Center

6/2000 - 5/2002

Functional complementation of insulin-resistance genes

Tihamer Orban, MD

Joslin Diabetes Center

6/2000 - 5/2002

Autoantigen vaccination in human type 1 diabetes mellitus

Lucia Rameh, PhD

Beth Israel Deaconess Med Ctr

6/2000 - 5/2002

PIP4kllb role in glucose homeostasis and insulin resistance

Mark Anderson, MD, PhD

Joslin Diabetes Center

8/2002 - 8/2003

Genetic analysis of the AIRE gene in type 1 DM

Young-Bum Kim, PhD

Beth Israel Deaconess Med Ctr

8/2002 - 7/2004

The potential role of the long-form of the leptin receptor in adipocytes.

Rohit Kulkarni, MD, PhD

Joslin Diabetes Center

8/2002 - 7/2004

Role of insulin receptors in islet alpha cell function

Gail Adler, MD, PhD

Brigham and Women's Hospital

8/2003 - 7/2005

Aldosterone and vascular disease in diabetes.

Sirano Dhe-Paganon, PhD

Joslin Diabetes Center

8/2003 - 7/2005

Structural determination of PKC and drug mapping

Jongsoon Lee, PhD

Joslin Diabetes Center

8/2003 - 7/2005

Role of GSK3b in fat cell differentiation

Medha Munshi, MD

Joslin Diabetes Center

8/2004 - 7/2008

Executive dysfunction in older diabetic patients

Shannon Turley, PhD

Dana-Farber Cancer Institute

8/2004 - 7/2006

The capture of dying beta cells by dendritic cells

Edward Feener, PhD

Joslin Diabetes Center

3/2005 - 2/2006

Ion Trap LC-MS/MS quantitation of peptides in vitreous humor

Timothy Graham, MD, PhD

Beth Israel Deaconess Med Ctr

8/2005 - 7/2007

RBP4 & maternal transmission of insulin resistance

Gail Musen, PhD

Joslin Diabetes Center

8/2005 - 7/2007

Functional correlates of gray matter changes in diabetes

Alan Davidson, PhD

Mass General Hospital

8/2006 - 7/2008

Zebrafish model of diabetic nephropathy

Amy Wagers, PhD

Joslin Diabetes Center

8/2006 - 7/2008

Circulating factors in diabetic wound healing

Erin Kershaw, MD

Beth Israel Deaconess Med Ctr

8/2007 - 7/2009

In Vivo role of adiponutrin in metabolic and energy homeostasis

Christian Rask-Madsen, MD, PhD

Joslin Diabetes Center

8/2007 - 7/2009

Role of PKC in diabetic retinopathy

Lloyd Paul Aiello, MD, PhD

Joslin Diabetes Center

8/2008 - 7/2010

Why do retinal vessels break through the ILM in PDR?

Josef Michael Kurtz, PhD

Mass. General Hospital

9/2008 - 8/2010

Characterization of diabetogenic CD4 cells in T1D

Giulio Romeo, MD

Joslin Diabetes Center

8/2008 - 7/2010

Profilin-1 in diet-induced insulin resistance

Michael Zeisberg, MD

Beth Israel Deaconess Med Ctr

8/2008 - 7/2009

Epigenetics of diabetic nephropathy

Sudha Biddinger, MD, PhD

Boston Children's Hospital

8/2009 - 7/2011

Defects in insulin signaling in the metabolic syndrome

Ho-Jin Koh, PhD

Joslin Diabetes Center

8/2009 - 7/2011

TRB3 modulates glucose-lipid metabolism in skeletal muscle

Libin Liu, PhD

Joslin Diabetes Center

8/2009 - 7/2011

Macrophage Cpe causes obesity in fatty fa/fa mice

Raul Mostoslavsky, MD, PhD

Mass. General Hospital

8/2009 - 7/2011

SIRT6 controls glucose homeostasis

Jennifer Sun, MD

Joslin Diabetes Center

8/2010 - 7/2012

Predicting treatment response in diabetic macular edema

Janice Zabolotny, PhD

Beth Israel Deaconess Med Ctr

8/2010 - 7/2012

Mechanisms to improve wound healing in diabetes

Jason Gaglia, MD

Joslin Diabetes Center

8/2011 - 7/2013

Imaging Islet-Antigen reactive peripheral T cells

Monika Niewczas, MD, PhD

Joslin Diabetes Center

8/2011 - 7/2013

Regulation of circulating sTNF receptors in diabetes

Aaron Cypess, MD, PhD

Joslin Diabetes Center

1/2013 - 12/2014

β3-Adrenergic receptor agonists on human brown adipose tissue

Stephan Kissler, PhD

Joslin Diabetes Center

1/2013 - 12/2014

How TAGAP variation impacts T cell migration in type 1 diabetes

F.M. Fisher, PhD

Beth Israel Deaconess Med Ctr

1/2014 - 12/2015

FGF21 induced white adipose tissue browning

Jongsoon Lee, PhD

Joslin Diabetes Center

1/2014 - 12/2015

The role of adipose tissue foam cells in lipid homeostasis and inflammation

Thomas Serwold, PhD

Joslin Diabetes Center

1/2015 - 12/2016

Antigen spreading in the initation of type 1 diabetes

Norbert Perrimon, PhD

Harvard Medical School

1/2015 - 12/2016

Activin regulation of glucagon action: a novel therapeutic opportunity for type 2 diabetes

Lijun Sun, PhD

Beth Israel Deaconess Med Ctr

1/2015 - 12/2016

Targeting activated mast cells in diabetic foot ulcers

Peng Yi, PhD

Joslin Diabetes Center

1/2016 - 12/2017

A CRISPR-Cas9 screening for genes regulating pancreatic beta cell proliferation

Ashley Vernon, MD

Brigham and Women's Hospital

1/2016 - 12/2017

Human adipose tissue microbiome in type 2 diabetes

Thomas McElrath, MD, PhD

Brigham and Women's Hospital

1/2017 - 12/2018

Circulating SerpinB1 and vulnerability to gestational diabetes

Sarah Lessard, PhD

Joslin Diabetes Center

1/2017 - 12/2018

Mechanisms of exercise resistance in diabetes

Cristina Aguayo- Mazzucato, MD, PhD

Joslin Diabetes Center

1/2018 - 12/2019

Induction of beta cell senescence by high fat diet and implications for diabetes

Eyal Dassau, PhD

Harvard School of Engineering and Applied Sciences

1/2018 - 12/2019

Can technology improve self-care in youth with Type-1 Diabetes?

Stephen Liberles, PhD

Harvard Medical School

4/2018 - 3/2020

The impact of vagal nutrient-sensing neurons on systemic metabolism

Amy Wagers, PhD

Joslin Diabetes Center

4/2018 - 3/2020

Hematologic mutations as potential predictors of diabetic complications

Sirano Dhe-Paganon, PhD

Dana-Farber Cancer Institute

5/2019 - 4/2021

Structural basis of XOR activation in obesity and metabolic syndrome

Aleksandar Kostic, PhD

Joslin Diabetes Center

5/2019 - 4/2021

Designing and testing novel probiotic strategies to curtail glycemic excursion

Matthew Lynes, PhD

Joslin Diabetes Center

7/2020 - 6/2022

Genetic determinants of 12, 13-diHOME biosynthesis in human obesity

Linus Tzu-Yen Tsai MD, PhD

Beth Israel Deaconess Med Ctr

7/2020 - 6/2022

The role of interferon regulatory factors in tanycytes during HFD-induced inflammation, obesity and glucose dysregulation