*Names in red are current Joslin Investigators. You can view their bio by clicking on the link.
|
Principal Investigator |
Applicant Institution |
Dates of Award |
Pilot Project Title |
|
Albert Edge, PhD |
Joslin Diabetes Center |
1986-87 |
Studies on carbohydrates of the insulin receptor |
|
Richard Jackson, MD
|
Joslin Diabetes Center |
1986-87 |
T cell receptor and MHC genes |
|
Elefteria Maratos-Flier, MD |
Beth Israel Deaconess Med Ctr |
1987-89 |
Effect of reovirus infection on gene expression |
|
Morris White, PhD
|
Joslin Diabetes Center |
1987-89 |
Relation between the insulin receptor and pp 60src in hepatoma cells |
|
Steve Rabinowe, MD |
Joslin Diabetes Center |
1987-88 |
The presence and significance of antiadrenal medullary antibodies in type 1 diabetes mellitus |
|
Raymonde Dumont (née Herskowitz) M.D. |
Joslin Diabetes Center |
1987-88 |
Transient hyperglycemia in children |
|
Joslin Diabetes Center |
1988-90 |
Transcriptional control by insulin during myogenesis |
|
|
Masakazu Hattori, MD, PhD |
Joslin Diabetes Center |
1988-90 |
Islet T-lymphocyte clones of type 1 diabetes patients |
|
Barry Goldstein,MD, PhD |
Joslin Diabetes Center |
1989-91 |
Molecular cloning of the rat insulin receptor cDNA |
|
Barbara Widom, MD |
Joslin Diabetes Center |
1989-90 |
Mechanism of weight gain during intensive insulin therapy |
|
Barbara Anderson, William Polonsky PhD, PhD |
Joslin Diabetes Center |
1990-91 |
Clinical and subclinical eating disorders in female patients with diabetes |
|
Christopher Rhodes, PhD |
Joslin Diabetes Center |
1990-92 |
The endopeptidic processing of insulin receptor |
|
Joslin Diabetes Center |
1991-92 |
YMXM motifs, SH2 domains and insulin action |
|
|
Heimo Riedel,PhD |
Joslin Diabetes Center |
1991-93 |
A genetic screen for receptor-substrate/ligand binding |
|
Peter Arvan, MD, PhD |
Beth Israel Deaconess Med Ctr |
1991-93 |
Secretory protein targeting in pancreatic B-cells |
|
Joslin Diabetes Center |
1992-94 |
Genetic dissection of T cell requirements for autoimmune diabetes |
|
|
Joslin Diabetes Center |
1993-95 |
The search for genes that cause diabetic embryopathy |
|
|
Joslin Diabetes Center |
1993-95 |
Role of vascular endothelial growth factor in diabetic retinopathy |
|
|
Joslin Diabetes Center |
1993-95 |
Molecular mechanisms of skeletal muscle insulin resistance |
|
|
Gokhan Hotamisligil, MD, PhD |
Harvard School of Public Health |
1995-97 |
Role of TNF receptors in obesity and insulin resistance |
|
Joslin Diabetes Center |
1994-96 |
Screening for mutations at the Rad locus, a candidate gene for NIDDM |
|
|
Bentley Cheatham, PhD |
Joslin Diabetes Center |
9/1995 - 11/1996 |
Role of Rab proteins in Glut4 translocation |
|
Elefteria Maratos-Flier, MD |
Joslin Diabetes Center |
12/1995 - 11/1997 |
MCH: A novel regulator of feeding behavior |
|
Joslin Diabetes Center |
1/1996 - 11/1996 |
Pregnancy and diabetic nephropathy in women with IDDM |
|
|
Arun Sharma, PhD |
Joslin Diabetes Center |
12/1996 - 11/1998 |
Cloning of an insulin gene transcription factor, RIPE3b1 |
|
Joslin Diabetes Center |
12/1996 - 11/1998 |
Novel mechanisms for nutrient regulation of insulin action |
|
|
Martin Myers, MD, PhD |
Joslin Diabetes Center |
12/1997 - 11/1999 |
Role of Leptin receptor signaling pathways in physiology |
|
Joslin Diabetes Center |
10/1998 - 9/2000 |
Glucose 6-P dehydrogenase and apoptosis in diabetes |
|
|
Christian Bjorbaek, PhD |
Beth Israel Deaconess Med Ctr |
10/1999 - 9/2001 |
Role of PIAS proteins in Leptin signaling and Leptin resistance |
|
Deborah Burks, PhD |
Joslin Diabetes Center |
10/1999 - 9/2000 |
The Role of IRS-2 in endocrine vascular function |
|
Joslin Diabetes Center |
6/2000 - 5/2002 |
Functional complementation of insulin-resistance genes |
|
|
Tihamer Orban, MD |
Joslin Diabetes Center |
6/2000 - 5/2002 |
Autoantigen vaccination in human type 1 diabetes mellitus |
|
Lucia Rameh, PhD |
Beth Israel Deaconess Med Ctr |
6/2000 - 5/2002 |
PIP4kllb role in glucose homeostasis and insulin resistance |
|
Mark Anderson, MD, PhD |
Joslin Diabetes Center |
8/2002 - 8/2003 |
Genetic analysis of the AIRE gene in type 1 DM |
|
Young-Bum Kim, PhD |
Beth Israel Deaconess Med Ctr |
8/2002 - 7/2004 |
The potential role of the long-form of the leptin receptor in adipocytes. |
|
Joslin Diabetes Center |
8/2002 - 7/2004 |
Role of insulin receptors in islet alpha cell function |
|
|
Gail Adler, MD, PhD |
Brigham and Women's Hospital |
8/2003 - 7/2005 |
Aldosterone and vascular disease in diabetes. |
|
Sirano Dhe-Paganon, PhD |
Joslin Diabetes Center |
8/2003 - 7/2005 |
Structural determination of PKC and drug mapping |
|
Jongsoon Lee, PhD |
Joslin Diabetes Center |
8/2003 - 7/2005 |
Role of GSK3b in fat cell differentiation |
|
Joslin Diabetes Center |
8/2004 - 7/2008 |
Executive dysfunction in older diabetic patients |
|
|
Shannon Turley, PhD |
Dana-Farber Cancer Institute |
8/2004 - 7/2006 |
The capture of dying beta cells by dendritic cells |
|
Edward Feener, PhD |
Joslin Diabetes Center |
3/2005 - 2/2006 |
Ion Trap LC-MS/MS quantitation of peptides in vitreous humor |
|
Timothy Graham, MD, PhD |
Beth Israel Deaconess Med Ctr |
8/2005 - 7/2007 |
RBP4 & maternal transmission of insulin resistance |
|
Gail Musen, PhD |
Joslin Diabetes Center |
8/2005 - 7/2007 |
Functional correlates of gray matter changes in diabetes |
|
Alan Davidson, PhD |
Mass General Hospital |
8/2006 - 7/2008 |
Zebrafish model of diabetic nephropathy |
|
Joslin Diabetes Center |
8/2006 - 7/2008 |
Circulating factors in diabetic wound healing |
|
|
Erin Kershaw, MD |
Beth Israel Deaconess Med Ctr |
8/2007 - 7/2009 |
In Vivo role of adiponutrin in metabolic and energy homeostasis |
|
Joslin Diabetes Center |
8/2007 - 7/2009 |
Role of PKC in diabetic retinopathy |
|
|
Joslin Diabetes Center |
8/2008 - 7/2010 |
Why do retinal vessels break through the ILM in PDR? |
|
|
Josef Michael Kurtz, PhD |
Mass. General Hospital |
9/2008 - 8/2010 |
Characterization of diabetogenic CD4 cells in T1D |
|
Joslin Diabetes Center |
8/2008 - 7/2010 |
Profilin-1 in diet-induced insulin resistance |
|
|
Michael Zeisberg, MD |
Beth Israel Deaconess Med Ctr |
8/2008 - 7/2009 |
Epigenetics of diabetic nephropathy |
|
Sudha Biddinger, MD, PhD |
Boston Children's Hospital |
8/2009 - 7/2011 |
Defects in insulin signaling in the metabolic syndrome |
|
Ho-Jin Koh, PhD |
Joslin Diabetes Center |
8/2009 - 7/2011 |
TRB3 modulates glucose-lipid metabolism in skeletal muscle |
|
Libin Liu, PhD |
Joslin Diabetes Center |
8/2009 - 7/2011 |
Macrophage Cpe causes obesity in fatty fa/fa mice |
|
Raul Mostoslavsky, MD, PhD |
Mass. General Hospital |
8/2009 - 7/2011 |
SIRT6 controls glucose homeostasis |
|
Joslin Diabetes Center |
8/2010 - 7/2012 |
Predicting treatment response in diabetic macular edema |
|
|
Janice Zabolotny, PhD |
Beth Israel Deaconess Med Ctr |
8/2010 - 7/2012 |
Mechanisms to improve wound healing in diabetes |
|
Joslin Diabetes Center |
8/2011 - 7/2013 |
Imaging Islet-Antigen reactive peripheral T cells |
|
|
Joslin Diabetes Center |
8/2011 - 7/2013 |
Regulation of circulating sTNF receptors in diabetes |
|
|
Aaron Cypess, MD, PhD |
Joslin Diabetes Center |
1/2013 - 12/2014 |
β3-Adrenergic receptor agonists on human brown adipose tissue |
|
Joslin Diabetes Center |
1/2013 - 12/2014 |
How TAGAP variation impacts T cell migration in type 1 diabetes |
|
|
F.M. Fisher, PhD |
Beth Israel Deaconess Med Ctr |
1/2014 - 12/2015 |
FGF21 induced white adipose tissue browning |
|
Jongsoon Lee, PhD |
Joslin Diabetes Center |
1/2014 - 12/2015 |
The role of adipose tissue foam cells in lipid homeostasis and inflammation |
|
Joslin Diabetes Center |
1/2015 - 12/2016 |
Antigen spreading in the initiation of type 1 diabetes |
|
|
Norbert Perrimon, PhD |
Harvard Medical School |
1/2015 - 12/2016 |
Activin regulation of glucagon action: a novel therapeutic opportunity for type 2 diabetes |
|
Lijun Sun, PhD |
Beth Israel Deaconess Med Ctr |
1/2015 - 12/2016 |
Targeting activated mast cells in diabetic foot ulcers |
|
Joslin Diabetes Center |
1/2016 - 12/2017 |
A CRISPR-Cas9 screening for genes regulating pancreatic beta cell proliferation |
|
|
Ashley Vernon, MD |
Brigham and Women's Hospital |
1/2016 - 12/2017 |
Human adipose tissue microbiome in type 2 diabetes |
|
Thomas McElrath, MD, PhD |
Brigham and Women's Hospital |
1/2017 - 12/2018 |
Circulating SerpinB1 and vulnerability to gestational diabetes |
|
Joslin Diabetes Center |
1/2017 - 12/2018 |
Mechanisms of exercise resistance in diabetes |
|
|
Joslin Diabetes Center |
1/2018 - 12/2019 |
Induction of beta-cell senescence by high-fat diet and implications for diabetes |
|
|
Eyal Dassau, PhD |
Harvard School of Engineering and Applied Sciences |
1/2018 - 12/2019 |
Can technology improve self-care in youth with Type-1 Diabetes? |
|
Stephen Liberles, PhD |
Harvard Medical School |
4/2018 - 3/2020 |
The impact of vagal nutrient-sensing neurons on systemic metabolism |
|
Joslin Diabetes Center |
4/2018 - 3/2020 |
Hematologic mutations as potential predictors of diabetic complications |
|
|
Sirano Dhe-Paganon, PhD |
Dana-Farber Cancer Institute |
5/2019 - 4/2021 |
Structural basis of XOR activation in obesity and metabolic syndrome |
|
Joslin Diabetes Center |
5/2019 - 4/2021 |
Designing and testing novel probiotic strategies to curtail glycemic excursion |
|
|
Matthew Lynes, PhD |
Joslin Diabetes Center |
7/2020 - 6/2022 |
Genetic determinants of 12, 13-diHOME biosynthesis in human obesity |
|
Linus Tzu-Yen Tsai MD, PhD |
Beth Israel Deaconess Med Ctr |
7/2020 - 6/2022 |
The role of interferon regulatory factors in tanycytes during HFD-induced inflammation, obesity and glucose dysregulation |
|
Ismail Sayed, PhD |
Beth Israel Deaconess Med Ctr |
4/2021-3/2023 |
Effects of novel lipids on on the NLRP3 inflammasome and impact on diabetogenesis in NOD model |
|
Daniel Zeve, MD, PhD |
Boston Children’s Hospital |
4/2021-3/2023 |
Use of human enteroids/organoids to induce K and L enteroendocrine cells that appropriately respond to nutrients in vitro and in vivo. |